9 results about "Melanocyte-stimulating hormone" patented technology

The invention discloses a robot optimal path planning method based on an improved angle skid optimization algorithm, and the method comprises the steps: designing a single-target optimization problem under a constraint condition based on the angle skid optimization algorithm, setting a target function as the shortest distance between a starting point and an end point, and determining the constraint condition; a good point set strategy is adopted to replace random node initialization distribution, and an adaptive dynamic weight, a dynamic weight, an adaptive coefficient, a Brownian motion random disturbance parameter and a random walk and adaptive t distribution disturbance strategy of step length adjustment are introduced. A hiding behavior, a blood jetting behavior, an escape behavior, a skin blackening and brightening behavior and a melanocyte stimulating hormone (MSH) rate formula of the algorithm are optimized respectively, and a planned path is optimized through the improved HLOA algorithm. Compared with the prior art, the method has the advantages that the convergence speed, the optimization precision and the global search capability of the angle exid optimization algorithm in robot path planning are improved, and the method is suitable for optimal path planning in a complex environment.

The present disclosure relates to novel peptide antagonists that inhibit binding of melanocyte stimulating hormone to the melanocortin 1 receptor. The peptide antagonists of the disclosure are useful in cosmetic compositions that prevent or reduce the appearance of skin discoloration caused by pigmentation. The disclosure further relates to cosmetic compositions comprising a peptide antagonist of the disclosure, and methods for their use for preventing or reducing the appearance of skin discoloration in a subject in need thereof.

The invention provides an application of alpha-melanocyte stimulant in treating asthma by inhibiting type II innate lymphocytes. An IL-7R-STAT pathway in activated lung ILC2 is inhibited through an alpha-MSH-MC5R axis, it is found that the neuroendocrine hormone alpha-MSH can target ILC2 to limit lung inflammation, and screening of new drugs for treating lung inflammation is facilitated.

The invention provides a medicinal and edible composition for treating vitiligo as well as a preparation and application thereof, and the medicinal and edible composition comprises the following components in parts by weight: 1-8 parts of peach kernel, 1-8 parts of galangal, 1-8 parts of angelica dahurica and 1-8 parts of black sesame. According to the invention, the peach kernel, the galangal, the radix angelicae and the black sesame which are homologous in medicine and food are combined, so that the effect of treating leucoderma is exerted. Animal experiments show that the effective rate of the peach kernel, galangal, angelica dahurica and black sesame medicine composition for treating vitiligo can reach 70%, the content of tyrosinase in serum of vitiligo model guinea pigs can be increased, synthesis of melanin is accelerated, meanwhile, the content of alpha-melanin cell stimulant in serum of the vitiligo model guinea pigs can be increased, and the curative effect is good. The generation of skin melanin is promoted, and melanin cells are protected.

The application discloses a kind of serum-free epidermal melanocyte culture medium and its application, method includes by dissolving adenine, hepatocyte growth factor (HGF), glutamine, retinoic acid, vitamin E, nicotinic acid, sodium selenite, sodium hyaluronate and recombination human type XVII collagen are configured into initial culture medium;Preparation of melanocyte stimulating hormone, endothelin-3, transferrin, triiodothyronine, cholesterol, neuroregulin 1 (NRG1), 3-isobutyl-1-methyl purine (IBMX), dibutyryl cyclic adenosine monophosphate (db-cAMP), cholera toxin, hydrocortisone and recombination human insulin mother liquor;Step three: according to culture and concentration, a certain amount of mother liquor of step two is added to initial culture medium.The culture medium can effectively promote human epidermal melanocyte proliferation, melanin accumulation and help to promote human umbilical cord mesenchymal stem cells into human epidermal melanocyte, provide key advantage for obtaining functional melanocyte with high activity and therapeutic potential.

Provided is a use of α-MSH or a promoter thereof in liver cancer; specifically, provided is a use of α-MSH, an analog thereof or a promoter thereof for preparing a pharmaceutical composition or preparation for: (i) inhibiting the growth of liver cancer cells, and / or (ii) treating liver cancer. The pharmaceutical composition or preparation can induce apoptosis of liver cancer cells, reducing the number of liver cancer cells and thus achieving an anti-tumor effect.

The invention belongs to the technical field of biology, and particularly relates to a tea source peptide with whitening and anti-aging functions and a preparation method and application thereof. According to the invention, tea protein is subjected to alkaline protease enzymolysis to obtain tea protein hydrolysate (TPH), and the peptide fragment composition of the tea protein hydrolysate (TPH) is analyzed by using an ultra-high performance liquid chromatography-mass spectrometry (UPLC-MS / MS) technology to screen out the peptide fragment with melanin generation inhibition and anti-aging functions. Experimental results show that the tea source peptides EGFG and FGDPHG can effectively inhibit tyrosinase activity in a cell-free system and show a remarkable free radical scavenging effect. In melanoma cells, the two can significantly inhibit synthesis of melanin induced by alpha-melanotropin (alpha-MSH), and have a significant antioxidant effect in an aging model of H2O2 induced oxidative stress. The whitening and anti-aging effects are further proved in a zebra fish model. The tea source peptide provided by the invention has whitening and anti-aging effects, and can be used as an active component in whitening and anti-aging functional foods, cosmetics and medicines.

The present invention relates to alpha-melanocyte stimulating hormone analogs targeting the melanocortin-1 receptor.

The invention relates to application of alpha-MSH or an accelerant thereof in liver cancer, and particularly discloses application of alpha-MSH, an analogue thereof or an accelerant thereof and application of alpha-MSH, an analogue thereof or an accelerant thereof to preparation of a pharmaceutical composition or a preparation, and the pharmaceutical composition or the preparation is used for (i) inhibiting growth of liver cancer cells; and / or (ii) treating liver cancer. The pharmaceutical composition or the preparation can induce apoptosis of liver cancer cells and reduce the number of liver cancer cells, so that the anti-tumor effect is achieved.