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Application of colla corii asini for preparing pharmaceutical for preventing or treating estrogen-related diseases

An estrogen and disease technology, which can be used in sexual diseases, bone diseases, drug combinations, etc.

Inactive Publication Date: 2018-05-25
SHAANXI UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far there is no report about the estrogen-like activity of donkey-hide gelatin

Method used

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  • Application of colla corii asini for preparing pharmaceutical for preventing or treating estrogen-related diseases
  • Application of colla corii asini for preparing pharmaceutical for preventing or treating estrogen-related diseases
  • Application of colla corii asini for preparing pharmaceutical for preventing or treating estrogen-related diseases

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Embodiment Construction

[0015] In order to enable those skilled in the art to better understand the technical solutions in the embodiments of the present invention, and to make the above-mentioned purpose, features and advantages of the present invention more obvious and understandable, the specific implementation of the present invention will be further described below in conjunction with the accompanying drawings illustrate.

[0016] It should be noted here that the descriptions of these embodiments are used to help understand the present invention, but are not intended to limit the present invention. In addition, the technical features involved in the various embodiments of the present invention described below may be combined with each other as long as they do not conflict with each other.

[0017] 1. Experimental materials

[0018] 1.1 Experimental animals

[0019] Healthy female non-pregnant mice, weighing 18-22g.

[0020] 1.2 Drugs

[0021] Test drug: donkey-hide gelatin.

[0022] Positiv...

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Abstract

The invention discloses a new usage of colla corii asini, and particularly relates to an application of the colla corii asini for preparing a pharmaceutical for preventing or treating estrogen-relateddiseases. Through a large number of experiments, it is discovered that the colla corii asini in the effective dosage can obviously improve the serum E2 content of normal female mice, and reduce the serum LH and FSH content of normal male mice; the colla corii asini in the effective dosage can obviously improve the uterine coefficient of the normal female mice; the colla corii asini group has theeffect of promoting the normal female uterus growth and development, and enables the endometrium to be thickened, the uterine cavity to be enlarged, and the number of glands to be increased; and the ovarian stroma of the ovarian tissue of the mice in the colla corii asini group is hyperaemia, follicles located in the different development stages are visible, and the obvious pathological change isnot seen. It is concluded that the colla corii asini has the estrogen-like effect to the normal female mice, the untoward effect is not existent after used, and the colla corii asini can be used for preventing or treating diseases, such as the female climacteric syndrome and the osteoporosis.

Description

technical field [0001] The invention relates to a new application of donkey-hide gelatin, in particular to an application of donkey-hide gelatin in the preparation of drugs for preventing or treating estrogen-related diseases. Background technique [0002] Estrogen is one of the most important hormones in humans and other higher animals, and has a wide range of physiological functions. Under normal circumstances, the level of sex hormones in the human body is relatively stable. Once it is out of balance, it will lead to abnormal secretion of sex hormones and cause various diseases. As a vital sex hormone in women, estrogen plays an irreplaceable role in women. The application of estrogen in the field of reproduction is also becoming more and more extensive. Estrogen plays an essential role in the development and maintenance of female sexual characteristics, the maturation of germ cells, the formation of fertilized eggs, embryo implantation and the maintenance of pregnancy. ...

Claims

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Application Information

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IPC IPC(8): A61K35/36A61P5/30A61P15/12A61P19/10
Inventor 张晓双胡锐刘继平史永恒刘颖
Owner SHAANXI UNIV OF CHINESE MEDICINE
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