Application of Miao-medicine radix chimonanthus extract in preparation of anti-AD (Alzheimer's Disease) products

Abstract

The invention belongs to the technical field of medicines, and discloses application of a Miao-medicine radix chimonanthus extract in preparation of anti-AD (Alzheimer's Disease) products, and an AD treatment medicine prepared by ethyl acetate extract of Miao-medicine radix chimonanthus. A preparation method of the ethyl acetate extract of Miao-medicine radix chimonanthus comprises the following steps of cleaning the radix chimonanthus by water, removing impurities, airing, crushing, soaking the powder into 70% ethyl alcohol for 16h, extracting by 70% ethyl alcohol for 5h in a heat reflux way,filtering, concentrating by an extracting solution, extracting by ethyl acetate, respectively rotating and evaporating the extracting solution, reducing pressure and concentrating, and volatizing thesolvent in a water bath pot with temperature lower than 65 DEG C, so as to obtain the ethyl acetate extract. The extracting site of the ethyl acetate of the Miao-medicine radix chimonanthus has the anti-AD activity.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the application of an extract of Miao medicine iron chopsticks in the preparation of anti-AD products. Background technique [0002] The seedling medicine iron chopsticks are the dry fine roots of Chimonanthus praecox (Linn.) Link. and Chimonan nitens Oliv. The synonym is also known as Tiegangcha and Wa Niaochai. It is a variety recorded in the 2003 edition of "Quality Standards for Traditional Chinese and Ethnic Medicinal Materials in Guizhou Province". The main clinical manifestations of senile dementia are progressive mental decline and psychomotor disturbance, mainly recent memory impairment. At present, almost all the drugs approved by the US FDA for the treatment of AD are cholinesterase inhibitors. The long-term efficacy is not satisfactory, and they are chemical drugs, which have certain liver and gastrointestinal side effects. The current clinical treatmen...

AI Technical Summary

Problems solved by technology

[0003] In summary, the existing problems in the prior art are: so far, due to the unclear pathogenesis of AD, there is still a lack of specific drugs for the treatment of DA in clinical practice. There is a lack of effective intervention in the occurrence and development of the disease; other studies on the Miao medicine Tiechoizi have not found that the ethyl acetate part of the Miao medicine Tiechopsticks has anti-AD activity, and they have not used this characteristic to prepare for the treatment of AD. Drugs for AD

Images