Application of TLR8 activator in preparing tuberculosis vaccine adjuvant and tuberculosis vaccine prepared from TLR8 activator

A tuberculosis vaccine and activator technology, applied in the field of biomedicine, can solve problems such as weak specificity and achieve the effect of strong protective effect

Active Publication Date: 2018-06-01
INST OF LAB ANIMAL SCI CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, there have been no relevant reports on the use of TLR8 receptor agonists in the preparation of tuberculosis vaccine adjuvants, which may be due to the following reasons: First, TLR7 and TLR8 are involved in intracellular localization, ligand types (ssRNA, etc.), downstream pathways, etc. Very similarly, less specific activators such as R848 can activate TLR7 and TLR8 at the same time, and induce the immune response caused by

Method used

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  • Application of TLR8 activator in preparing tuberculosis vaccine adjuvant and tuberculosis vaccine prepared from TLR8 activator
  • Application of TLR8 activator in preparing tuberculosis vaccine adjuvant and tuberculosis vaccine prepared from TLR8 activator
  • Application of TLR8 activator in preparing tuberculosis vaccine adjuvant and tuberculosis vaccine prepared from TLR8 activator

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] The components of the tuberculosis vaccine in this example are: 25 μg of TL8-506, 450 μg of aluminum hydroxide gel, and 10 μg of ESAT-6;

[0047] The preparation method is as follows: respectively take selected weights of TL8-506, aluminum hydroxide gel and ESAT-6, mix them evenly, and let them stand for 1 hour to obtain the product.

Embodiment 2

[0049] The components of the tuberculosis vaccine in this example are: TL8-506 25.2 μg, aluminum hydroxide gel 450 μg, ESAT-6 10.8 μg;

[0050] The preparation method is as follows: respectively take selected weights of TL8-506, aluminum hydroxide gel and ESAT-6, mix them evenly, and let them stand for 1 hour to obtain the product.

Embodiment 3

[0052] The composition of present embodiment tuberculosis vaccine is: 9 μg, aluminum hydroxide gel 900 μg, ESAT-6 4.5 μg;

[0053] The preparation method is as follows: respectively take selected weights of TL8-506, aluminum hydroxide gel and ESAT-6, mix them evenly, and let them stand for 1 hour to obtain the product.

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Abstract

The invention belongs to the field of biological medicine and specifically relates to application of a TLR8 activator in preparing a tuberculosis vaccine adjuvant and a tuberculosis vaccine prepared from the TLR8 activator. The TLR8 activator has the following structural formula: FORMULA shown in the description. Research finds that the TLR8 activator TL8-506 provides a protection effect when theimmunized mouse is attacked by mycobacterium tuberculosis, and thus can be adopted as an adjuvant of the tuberculosis vaccine; according to further research, the TLR8 activator TL8-506 combined with aluminum hydroxide gel provides a stronger protection effect than aluminum hydroxide gel when the immunized mouse is attacked by mycobacterium tuberculosis.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to the use of a TLR8 activator in preparing a tuberculosis vaccine adjuvant and the prepared tuberculosis vaccine. Background technique [0002] Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (M.tuberculosis, MTB), which seriously endangers human health. Tuberculosis is the biggest killer worldwide after AIDS caused by a single infectious agent. Currently, 1 / 3 of the world's population has been infected with MTB. According to WHO statistics, in recent years, there are about 9 million new tuberculosis cases and 1.5 million deaths in the world every year. my country is one of the 22 countries with a high burden of tuberculosis in the world, and the number of cases is second only to India, ranking second in the world. Bacillus Calmette Guérin (BCG) is currently the only tuberculosis vaccine approved for use in humans. Although it has a certain ...

Claims

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Application Information

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IPC IPC(8): A61K39/39A61K39/04A61P31/06
CPCA61K39/04A61K39/39A61K2039/55505A61K2039/55511A61K2300/00
Inventor 唐军秦川占玲俊孙萌萌
Owner INST OF LAB ANIMAL SCI CHINESE ACAD OF MEDICAL SCI
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