The invention discloses a preparation process of an acid-base compound Magni coating and relates to a metal surface antiseptic treatment process. The preparation process comprises the procedure of pretreatment conducted before coating, preparation of the coating and treatment conducted after coating, wherein the procedure of preparation of the coating comprises the steps of firstly, conducting potassium chloride galvanization on the surface of a workpiece, and then conducting zincate galvanization, wherein the steps of 21, potassium chloride galvanization, 22, washing III, 23, zincate galvanization, 24, washing IV, 25, film removal and 26, washing V are included; the procedure of treatment conducted after coating comprises the steps of 31, ultralow chromium passivation, 32, washing VI and 33, drying. According to the preparation process of the acid-base compound Magni coating, the potassium chloride galvanization process and the zincate galvanization process are combined together, product quality can be well stabilized, production efficiency is greatly improved, production line operation cost is lowered, the coating on the surface of a product prepared through the preparation process is uniform, surface quality is good, the preparation process has the advantages that the coating speed is high, drying can be conducted easily, product defects are few, the service life of the product is prolonged, the ultralow chromium passivation process is adopted, sewage treatment cost is lowered, and the preparation process is easy to use and popularize.