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Traditional Chinese medicine composition for preventing and treating liver injury

A composition, technology of traditional Chinese medicine, applied in the field of medicine

Inactive Publication Date: 2018-06-05
INNER MONGOLIA TIANQI HAN&MONGOLIA PHARMA CO +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there is no ideal drug for the effective prevention and treatment of alcoholic liver injury in clinical practice. Therefore, there is an urgent need for safe, effective and clear-cut anti-alcoholic liver injury drugs in the market

Method used

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  • Traditional Chinese medicine composition for preventing and treating liver injury
  • Traditional Chinese medicine composition for preventing and treating liver injury
  • Traditional Chinese medicine composition for preventing and treating liver injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1 Protective effect on alcoholic liver injury

[0024] 1. Experimental method

[0025] 1.1 Sample: Take the extracts in the table, mix well, and set aside. During the test, distilled water was used as solvent to prepare the test substance, and it was stored in cold storage.

[0026] formula

Recipe weight (Kg)

Pueraria Root Extract

10

Ligustrum extract

5

Hovenia dulcis seed extract

5

Schisandra Extract

3

Gardenia Extract

3

Wolfberry Extract

3

[0027] The preparation method of each extract is as follows:

[0028] Pueraria root extract: Take Pueraria root, add 8 times the weight of water to decoct twice, each time for 1.5 hours, combine the decoction, filter, concentrate the filtrate, and dry to obtain.

[0029] Ligustrum lucidum extract: take Ligustrum lucidum, add 8 times the weight of water to decoct twice, each time for 1.5 hours, combine the decoction, filter, concentrate the fil...

Embodiment 2

[0065] Example 2 Safety Evaluation Test

[0066] 1. Experimental method

[0067] 1.1 Sample: Example 1 sample. During the test, distilled water was used as solvent to prepare the test substance, and it was stored in cold storage.

[0068] 1.2 Experimental animals:

[0069] 1.2.1 Breeding environment and source of feed: The experimental animal room use license number is SYXK (Sichuan) 2011-043. Barrier system, temperature 20-25 °C, relative humidity 40%-70%. The feed was obtained from Sichuan Academy of Medical Sciences. Sichuan Provincial People's Hospital Laboratory Animal Research Institute, the production license number is SCXK (Sichuan) 2015-01.

[0070] 1.2.2 Animals: See Table 4 for the use of relevant experimental animals.

[0071] Table 4 List of experimental animals

[0072]

[0073] 1.3 Dose selection and test substance administration:

[0074] 1.3.1 Acute oral toxicity test: a dose group of 15000mg / kg.BW was set up, and 20ml / kg.BW was administered orally. ...

Embodiment 3

[0097] Example 3 Capsules

[0098] Name of raw material

[0099] Preparation method: Take the above-mentioned 6 kinds of extracts, mix them evenly, make granules by dry method, add magnesium stearate, mix them evenly, put them into capsules, and get ready.

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PUM

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Abstract

The invention relates to a traditional Chinese medicine composition for preventing and treating liver injury. The traditional Chinese medicine composition is prepared from the following raw materialsin parts by weight: 80-120 parts of a radix puerariae extract, 40-60 parts of a fructus ligustri lucidi extract, 40-60 parts of a raisin tree seed extract, 24-36 parts of a schisandra chinensis extract, 24-36 parts of a wolfberry fruit extract and 24-36 parts of gardenia extract.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to a traditional Chinese medicine composition for preventing and treating liver damage. Background technique [0002] Liver disease caused by liver injury has become an important problem in the global medical field. Liver injury includes chemical liver injury, drug-induced liver injury, immune liver injury and alcoholic liver injury. The most common of these is alcoholic liver damage. Alcoholic liver damage (ALD) is a liver disease caused by long-term heavy drinking. Liver cirrhosis, severe alcoholism can induce extensive liver cell necrosis or even liver failure. [0003] At present, the pathogenesis of ALD is not very clear, and free radicals and lipid peroxidation mediated by them are considered to be the main pathogenic factors. Ethanol can produce a large number of free radicals during liver metabolism: O2-, H2O2, OH-, C2H5O- and C2H5OH-. Excessive free radicals can cause ...

Claims

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Application Information

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IPC IPC(8): A61K36/815A61P1/16
CPCA61K36/488A61K36/57A61K36/638A61K36/72A61K36/744A61K36/79A61K36/815A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2300/00
Inventor 佘宜寰隋岩宋华先韩风雨于秀玲
Owner INNER MONGOLIA TIANQI HAN&MONGOLIA PHARMA CO
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