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Gynostemma pentaphylla rinsing liquid with inhibitory effect on urothelium malignant potential proliferation, preparation method and application thereof

A technology of urothelium and Gynostemma pentaphyllum, which is applied in the field of medical phytochemistry, can solve the problems of low yield and consumption of medicinal resources, and achieve a strong inhibitory effect

Inactive Publication Date: 2018-06-22
MINZU UNIVERSITY OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

If traditional methods are used for separation, not only a large amount of medicinal resources are consumed, but also the yield is very low

Method used

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  • Gynostemma pentaphylla rinsing liquid with inhibitory effect on urothelium malignant potential proliferation, preparation method and application thereof
  • Gynostemma pentaphylla rinsing liquid with inhibitory effect on urothelium malignant potential proliferation, preparation method and application thereof
  • Gynostemma pentaphylla rinsing liquid with inhibitory effect on urothelium malignant potential proliferation, preparation method and application thereof

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Embodiment 1

[0018] The preparation of embodiment 1 compound of the present invention

[0019] Extract the coarse powder of the dried whole herb of Gynostemma pentaphyllum with 80% ethanol at 80°C for 3 times under reflux, the time of 3 times of reflux extraction is 2h, 2h and 1h, then combine the extracts, recover the solvent under reduced pressure to obtain ethanol extraction The extract is concentrated under reduced pressure to obtain the ethanol extract extract; the extract is obtained after the ethanol extraction extract is subjected to high temperature and high pressure treatment at 125°C and 0.24MPa for 3 hours, and the extract is fully soaked and adsorbed by HP20 resin. Ethanol is used for elution, the eluate is concentrated under reduced pressure, and then freeze-dried to obtain liquid medicine powder, which is prepared according to the ratio of 100 mg / ml physiological saline. Named Gynostemma lavage solution T1.

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Abstract

The invention discloses gynostemma pentaphylla rinsing liquid with an inhibitory effect on urothelium malignant potential proliferation and a preparation method and application thereof. The rinsing liquid contains rich flavone and saponin components; the preparation method of the rinsing liquid comprises the steps that the reflux extraction of the coarse powder of the dried gynostemma pentaphyllais conducted through ethanol solution, and the extractum extracted by ethanol is obtained by conducting vacuum concentration; the extractum is absorbed by using macroporous resin after high-temperature and high-pressure processing is conducted on the extractum, and the extractum is desorbed to obtain gynostemma pentaphylla extracts; gynostemma pentaphylla powder extracts are obtained after freezing and drying are conducted, and the gynostemma pentaphylla rinsing liquid is obtained by conducting proportioning by using normal saline. Pharmacodynamic experiments reveal that the gynostemma pentaphylla rinsing liquid has a more significant effect on inhibiting the urothelium malignant potential proliferation. The gynostemma pentaphylla rinsing liquid has the advantages of being simple in preparation, safe in components, free from toxins and side effects, stable in active ingredients and simple in rinsing manner.

Description

technical field [0001] The present invention relates to a kind of mixed medicinal solution containing Gynostemma flavonoids and Gynosides, in particular to a mixture of flavonoids and saponins which are extracted from Gynostemma pentaphyllum and have the ability to resist malignant hyperplasia of urothelium; The preparation method relating to the mixture and the application of the compound in medicine belong to the field of medical phytochemistry. Background technique [0002] Gynostemma pentaphylla is the whole herb of Gynostemma pentaphyllum (Thunb.) Makino of Cucurbitaceae (Cucurbitaceae) Gynostemma genus (Gynostemma), which has heat-clearing and detoxifying functions. [0003] The most important medicinal ingredients in Gynostemma pentaphyllum are flavonoids and saponins. Studies have shown that the total extract of Gypenosides has a strong effect of inhibiting the proliferation and proliferation of cancer cells, and the total extract of Gypenoside flavonoids has a stro...

Claims

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Application Information

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IPC IPC(8): A61K36/424A61K9/08A61P35/00
CPCA61K9/0034A61K9/08A61K36/424A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61K2236/55
Inventor 朴香兰常拓邢韶芳
Owner MINZU UNIVERSITY OF CHINA
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