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A kind of medicine for treating esophageal squamous cell carcinoma and preparation method thereof

A technology for esophageal squamous cell carcinoma and drugs, which is applied in the development and application of anticancer drugs

Active Publication Date: 2021-06-22
NANYANG CITY CENT HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The efficacy of the above-mentioned vascular therapy drugs in esophageal squamous cell carcinoma has not been recorded and involved in the prior art or common technical knowledge. argument

Method used

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  • A kind of medicine for treating esophageal squamous cell carcinoma and preparation method thereof
  • A kind of medicine for treating esophageal squamous cell carcinoma and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] A medicine for treating esophageal squamous cell carcinoma, which is prepared from the following raw materials: arctigenin 10g, olive oil 30g, polyoxyethylene sesame oil 40g, glycerin 40g, salvia miltiorrhiza 20g, chuanqiong 10g.

[0031] The medicine preparation method for the treatment of esophageal squamous cell carcinoma is:

[0032] 1. Take the prescribed amount of Salvia Miltiorrhiza and Chuanqiong, crush it into 2 mm fine powder, add 8 times the weight of water, heat to 80 degrees, keep it for 10 hours, stir and extract, filter and concentrate to a concentrated solution with a relative density of 1.3, and vacuum dry. get the extract;

[0033] 2. Add arctigenin, olive oil, polyoxyethylene sesame oil, and glycerin to the extract obtained in step 1, stir and mix to form a nanoemulsion;

[0034] 3. Add water to the nanoemulsion obtained in step 2 according to the weight ratio of 15:1, and mix evenly to obtain a nanoemulsion dilution.

[0035] The particle size was ...

Embodiment 2

[0037] A medicine for treating esophageal squamous cell carcinoma, which is prepared from the following raw materials: arctigenin 15g, olive oil 40g, polyoxyethylene sesame oil 50g, glycerin 50g, salvia miltiorrhiza 45g, Chuanqiong 20g.

[0038] The medicine preparation method for the treatment of esophageal squamous cell carcinoma is:

[0039] 1. Take the prescription amount of Salvia Miltiorrhiza and Chuanqiong, crush it into 5 mm fine powder, add 10 times the weight of water, heat to 90 degrees, keep it for 8 hours, extract with ultrasonic stirring, filter and concentrate to a concentrated solution with a relative density of 1.2, and vacuum dry , get the extract;

[0040] 2. Add arctigenin, olive oil, polyoxyethylene sesame oil, and glycerin to the extract obtained in step 1, and ultrasonically stir and mix evenly to form a nanoemulsion;

[0041] 3. Add water to the nanoemulsion obtained in step 2 according to the weight ratio of 25:1, and mix evenly to obtain a nanoemulsi...

Embodiment 3

[0044] A medicine for treating esophageal squamous cell carcinoma, which is prepared from the following raw materials: arctigenin 10g, olive oil 30g, polyoxyethylene sesame oil 50g, glycerin 50g, salvia miltiorrhiza 40g, Chuanqiong 10g.

[0045] The medicine preparation method for the treatment of esophageal squamous cell carcinoma is:

[0046] 1. Take the prescribed amount of Salvia miltiorrhiza and Chuanqiong, crush it into 4 mm fine powder, add 12 times the weight of water, heat to 95 degrees, keep it for 9 hours, extract it ultrasonically, filter it, concentrate it into a concentrated solution with a relative density of 1.1, and dry it in vacuum. get the extract;

[0047] 2. Add the arctigenin, olive oil, polyoxyethylene sesame oil, and glycerol of the weight to the extract obtained in step 1, and mix them uniformly by ultrasonic to form a nanoemulsion;

[0048] 3. Add water to the nano-emulsion obtained in step 2 according to the weight ratio of 20:1, and mix evenly to o...

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Abstract

The invention discloses a medicine for treating esophageal squamous cell carcinoma and a preparation method thereof. The drug is the combined drug of arctigenin, salvia miltiorrhiza, and Chuanqiong, which shows a significant inhibitory effect on human esophageal squamous cell carcinoma at a certain ratio. The milk system can form the drug into a stable and uniform solution, and the in vivo experiments have proved that it has a high and significant therapeutic effect on esophageal squamous cell carcinoma.

Description

technical field [0001] The invention belongs to the technical field of cancer treatment and relates to the development and application of anticancer drugs. Background technique [0002] Esophageal squamous cell carcinoma is a malignant tumor that occurs in the epithelial tissue of the esophagus. my country is an area with a high incidence of esophageal squamous cell carcinoma, second only to gastric cancer. Treatment of esophageal squamous cell carcinoma mainly uses surgery, radiotherapy, chemotherapy and other methods. As we all know, the above methods are extremely harmful to the patient, and there is no guarantee that the patient will recover after treatment. How to develop drugs and therapeutic methods that can effectively treat esophageal squamous cell carcinoma has great practical social and economic significance to solve the problems faced by esophageal squamous cell carcinoma. [0003] There are several therapeutic agents in the prior art. In the treatment of lung ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/537A61P35/00A61K31/365
CPCA61K31/365A61K36/236A61K36/537A61K2236/331A61P35/00A61K2300/00
Inventor 岳恺
Owner NANYANG CITY CENT HOSPITAL
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