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Bauhinia extract and its extraction method and application in the preparation of antithrombotic drugs

A technology of antithrombotic drugs and extracts, applied in the field of medicine or/and health care products, can solve the problem that there is no Bauhinia leaf and the like

Active Publication Date: 2021-06-18
HENAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no relevant report on the treatment of thrombus in rats by Bauhinia leaves

Method used

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  • Bauhinia extract and its extraction method and application in the preparation of antithrombotic drugs
  • Bauhinia extract and its extraction method and application in the preparation of antithrombotic drugs
  • Bauhinia extract and its extraction method and application in the preparation of antithrombotic drugs

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Embodiment 1

[0014] An extraction method of Bauhinia extract, specifically: heating and extracting 4.5 kg of dried Bauhinia leaves with 45 L of ethanol with a concentration of 70% at 50°C for 3 times, each extraction for 3 hours, after the extraction is completed, the extracts are combined and subjected to decompression Concentrate and dry to obtain the total extract. The total extract was dissolved in water and passed through D101 macroporous resin, and eluted with 0, 20%, 40%, 60%, 95% ethanol-water mixture gradient, and 20% of the sample was mixed with silica gel and then passed through a decompression column, with a volume Gradient elution with dichloromethane-methanol mixture with a ratio of 10:1, 8:1, 5:1, and 3:1, the 5:1 part was dissolved in methanol, and purified by Sephadex LH-20 column to obtain Bauhinia extract 0.9 g.

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Abstract

The invention relates to a method for extracting Bauhinia extract, which is characterized in that Bauhinia leaves are heated and extracted with ethanol, and the extract is concentrated and dried under reduced pressure to obtain the total extract; the total extract is passed through D101 macroporous resin, and 0-95 % ethanol-water mixture for gradient elution, 20% part of the sample was mixed and passed through a decompression column, then gradient eluted with dichloromethane-methanol mixture, and passed through a Sephadex LH-20 column to obtain the Bauhinia extract. The present invention finds through tests that the bauhinia extract has better anticoagulant effect and remarkable curative effect, and can be used for preparing antithrombotic medicine.

Description

technical field [0001] The invention belongs to the technical field of medicine and / or health products, and in particular relates to a bauhinia extract and its extraction method and its application in the preparation of antithrombotic drugs. Background technique [0002] Thrombosis is the basic pathological process of many diseases such as myocardial infarction, ischemic fragmentation, deep vein thrombosis, etc. It seriously endangers human health. Its formation is related to the aggregation and adhesion of platelets, endogenous and exogenous It is closely related to the blood coagulation system and the formation of fibrin. According to the survey report of the World Health Organization, the death caused by thrombosis disease due to atherosclerosis has been ranked first. Arterial thrombosis is due to atherosclerosis, plaque instability and plaque rupture, causing platelets in the blood to aggregate, activating the blood coagulation system in the body, and finally leading to...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/48A61P7/02A61K127/00
CPCA61K36/48A61K2236/333A61K2236/39A61K2236/51A61K2236/55
Inventor 康文艺李昌勤何楠王鹏禹呼谧允张晓凤
Owner HENAN UNIVERSITY
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