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Cercis chinensis extract, extraction method thereof, and application of same for preparation of antithrombus medicine

An extraction method and extraction technology, applied in the field of medicine or/and health care products, can solve the problems such as the lack of Bauhinia leaves

Active Publication Date: 2018-09-28
HENAN UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, there is no relevant report on the treatment of thrombus in rats by Bauhinia leaves

Method used

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  • Cercis chinensis extract, extraction method thereof, and application of same for preparation of antithrombus medicine
  • Cercis chinensis extract, extraction method thereof, and application of same for preparation of antithrombus medicine
  • Cercis chinensis extract, extraction method thereof, and application of same for preparation of antithrombus medicine

Examples

Experimental program
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Embodiment 1

[0014] An extraction method of Bauhinia extract, specifically: heating and extracting 4.5 kg of dried Bauhinia leaves with 45 L of ethanol with a concentration of 70% at 50°C for 3 times, each extraction for 3 hours, after the extraction is completed, the extracts are combined and subjected to decompression Concentrate and dry to obtain the total extract. The total extract was dissolved in water and passed through D101 macroporous resin, and eluted with 0, 20%, 40%, 60%, 95% ethanol-water mixture gradient, and 20% of the sample was mixed with silica gel and then passed through a decompression column, with a volume Gradient elution with dichloromethane-methanol mixture with a ratio of 10:1, 8:1, 5:1, and 3:1, the 5:1 part was dissolved in methanol, and purified by Sephadex LH-20 column to obtain Bauhinia extract 0.9 g.

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Abstract

The invention relates to an extraction method of a Cercis chinensis extract, wherein the method includes steps of: performing heating extraction to Cercis chinensis leaves with ethanol, performing pressure reduced concentration and drying to an extract liquid to obtain a total extract; treating the total extract through a D101 macroporous resin and performing gradient elution with a 0-95% ethanol-water mixed liquid; performing sample blending to the 20% part, treating the sample through a pressure reduced column and performing gradient elution with a dichloromethane-methanol mixed liquid; andtreating the sample on a Sephadex LH-20 column to prepare the Cercis chinensis extract. The Cercis chinensis extract has good anticoagulation effect, has significant therapy effect and can be used forpreparing an antithrombus medicine.

Description

technical field [0001] The invention belongs to the technical field of medicine and / or health products, and in particular relates to a bauhinia extract and its extraction method and its application in the preparation of antithrombotic drugs. Background technique [0002] Thrombosis is the basic pathological process of many diseases such as myocardial infarction, ischemic fragmentation, deep vein thrombosis, etc. It seriously endangers human health. Its formation is related to the aggregation and adhesion of platelets, endogenous and exogenous It is closely related to the blood coagulation system and the formation of fibrin. According to the survey report of the World Health Organization, the death caused by thrombosis disease due to atherosclerosis has been ranked first. Arterial thrombosis is due to atherosclerosis, plaque instability and plaque rupture, causing platelets in the blood to aggregate, activating the blood coagulation system in the body, and finally leading to...

Claims

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Application Information

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IPC IPC(8): A61K36/48A61P7/02A61K127/00
CPCA61K36/48A61K2236/333A61K2236/39A61K2236/51A61K2236/55
Inventor 康文艺李昌勤何楠王鹏禹呼谧允张晓凤
Owner HENAN UNIVERSITY
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