Method for separating limonin compounds from narrow-leaf cortex dictamni

A technology of limonoids and fresh white peel, which is applied in the directions of steroids and organic chemistry, and can solve the problems of serious pollution, low efficiency and complicated operation.

Inactive Publication Date: 2018-11-02
CHINA PHARM UNIV
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Problems solved by technology

[0004] The invention provides a method for isolating limonoids from the fresh bark of P. angustifolia in combination with the prior art, which solves the disadvantages of traditional methods such as high cost, serious pollution, cumbersome operation, low efficiency, and difficult purification.

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  • Method for separating limonin compounds from narrow-leaf cortex dictamni
  • Method for separating limonin compounds from narrow-leaf cortex dictamni
  • Method for separating limonin compounds from narrow-leaf cortex dictamni

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Embodiment Construction

[0065] In order to make the object, technical solution and advantages of the present invention more clear, the present invention will be further described in detail below in conjunction with the accompanying drawings and embodiments.

[0066] figure 1 It is the implementation flow of the method for isolating limonoids from the fresh bark of Diana angustifolia provided by the embodiment of the present invention. It mainly includes the following 4 steps:

[0067] Extraction: Take 10kg of crushed fresh skin of Alba angustifolia, add 25L of 85% ethanol solution, soak at room temperature for 6 hours, heat and reflux for extraction for 4 hours, filter, collect the filtrate, add 25L of 85% ethanol solution to the filter residue, heat and reflux for extraction for 3 hours, repeat the above operation , a total of 3 times of heating and reflux extraction, the heating time is 4h, 3h, 3h respectively. The three filtrates were combined and concentrated to extract 565g of dry extract.

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Abstract

The invention relates to a method for separating and enriching limonin compounds. The method is characterized by comprising the following steps: heating ground narrow-leaf cortex dictamni with an ethanol solution, performing reflux extraction for 3-4 times, filtering, merging the filtrate, respectively extracting with petroleum ether, dichloromethane and ethyl acetate after concentrating, selecting the extraction fraction of the dichloromethane, combining silica gel column chromatography, Sephadex LH-20, preparative HPLC (High Performance Liquid Chromatography), recrystallization and other separation and purification means, and separating the limonin compounds. The method is high in separation efficiency, slight in pollution and low in cost and has excellent popularization and applicationvalue.

Description

Technical field: [0001] The invention belongs to the field of separation of natural products, and in particular relates to a method for separating limonoids from the fresh bark of Dionysus angustifolia. Background technique: [0002] Narrow leaf white fresh skin, also known as Xinjiang white fresh skin, belongs to the perennial herbaceous plant of Rutaceae white fresh, is a unique Chinese medicinal material in my country, and is often used as a substitute for traditional Chinese medicine white fresh in Xinjiang. It has a bitter taste and a cold nature. It has the effects of clearing away heat and detoxification, expelling wind and dampness, killing insects and relieving itching. After the root bark is used as medicine, it can be used to treat rheumatism, bleeding, itching, jaundice, chronic hepatitis, skin diseases and other diseases. In fact, there are two main types of active ingredients in the fresh bark of Alba angustifolia: furoquinoline alkaloids and limonoids. Among...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07J73/00C07D493/04C07D307/88
CPCC07D307/88C07D493/04C07J73/008
Inventor 孙建博王莹李强强
Owner CHINA PHARM UNIV
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