Detection kit for antinuclear antibody repertoires
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A detection kit and anti-nuclear antibody spectrum technology are applied in the field of detection kits for anti-nuclear antibody spectrum, which can solve problems such as low antibody detection efficiency and achieve the effect of improving detection efficiency
Pending Publication Date: 2018-11-13
宙斯生命科技(常州)有限公司
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[0003] The technical problem to be solved by the present invention is to provide a detection kit for ant
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[0017] In order to understand the technical means, creative features, objectives and effects of the present invention clearly, the present invention will be further described below in conjunction with specific embodiments.
[0018] A detection kit for antinuclear antibody spectrum, said kit comprising,
[0019] Composite microbead suspension, the composite microbead suspension contains a plurality of microbeads, wherein some of the microbeads are respectively coated with different types of autoantigens, and some of the microbeads are coated with autoantigens prepared from HEp-2 cells. Antigens, some of the microbeads are coated with an antigen that can detect non-specific antibodies in patient samples, and the remaining microbeads are four standard control microbeads;
[0020] A fluorescent marker, which is phycoerythrin-labeled goat anti-human IgG (specific γ chain);
[0021] A sample diluent containing phosphate buffer;
[0022] Washing solution, the sample diluent contain...
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Abstract
The invention discloses a detection kit for antinuclear antibody repertoires, and belongs to the technical field of detection kits. The detection kit comprises a composite micro bead suspension, a fluorescence indicator and a sample diluent, wherein a plurality of micro beads are contained in the composite micro bead suspension; a part of micro beads are coated with different types of autologous antigens respectively, a part of micro beads are coated with antigens prepared from HEP-2 cells, a part of micro beads are coated with antigens capable of detecting non-specific antibodies in patient samples, and the remaining micro beads are four types of standard control micro beads; the fluorescence indicator is phycoerythrin labeled goat-anti-human IgG (specific gamma chain); the sample diluentis a scrubbing solution. The detection for a plurality of autologous antibodies can be performed for one patient sample inside the same hole, so that auxiliary diagnosis is provided for various systemic autoimmune diseases such as systemic lupus erythematosus (SLE), rheumatoid arthritis, scleroderma, polymyositis, mixed connective tissue disease (MCTD), drug-induced SLE and sjogren syndrome.
Description
technical field [0001] The invention relates to a detection kit for antinuclear antibody spectrum, belonging to the technical field of detection kits. Background technique [0002] Although the exact etiology of autoimmune diseases is unknown at present, it is certain that there are specific autoantibodies in patients with various autoimmune connective tissue diseases. For patients with suspected various connective tissue diseases, SSA52 kDa, SSA 60 kDa, SSB, Sm, U snRNP B / B', U1 snRNP 68, U1 snRNP A, U1 snRNPC, Scl-70, Jo-1 should be tested jointly and frequently , Centromere B, PM Scl, Nucleosome, Ribosomal P, PCNA, dsDNA, Histone H, Histone HLY and M2 autoantibodies, especially these IgG antibodies. In the prior art, the detection by the kit is performed separately, and the efficiency is low. Contents of the invention [0003] The technical problem to be solved by the present invention is to provide a detection kit for anti-nuclear antibody spectrum, which solves the ...
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