Application of allyl methyl trisulfide in preparation of product for preventing and treating drug-induced liver injury

A technology of allyl methyl trisulfide and liver damage, which is applied in the field of medicine and can solve problems such as unsatisfactory effects

Inactive Publication Date: 2018-11-30
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently, N-acetylcysteine ​​(NAC) is the only antidote for APAP hepatotoxicity, but its effect is not satisfactory

Method used

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  • Application of allyl methyl trisulfide in preparation of product for preventing and treating drug-induced liver injury
  • Application of allyl methyl trisulfide in preparation of product for preventing and treating drug-induced liver injury
  • Application of allyl methyl trisulfide in preparation of product for preventing and treating drug-induced liver injury

Examples

Experimental program
Comparison scheme
Effect test

experiment example

[0047] Experimental materials and experimental methods

[0048] 1. Main materials

[0049] APAP was purchased from Sinopharm Chemical Reagent Co., Ltd.; AMTS was purchased from Hubei Xinkang Pharmaceutical Co., Ltd.; alanine aminotransferase (ALT) aspartate aminotransferase (AST) kit was purchased from Ningbo Meikang Biotechnology Co., Ltd.; malondialdehyde ( MDA) assay kit was purchased from Beyond Biotechnology Co., Ltd.; Nrf-2 and p-62 primary antibodies were purchased from cell signaling technology; HO-1, γ-GCS, NQO-1 and SOD primary antibodies were purchased from Santa Cruz; CYP2E1- Antibody was purchased from Abcam; LC3 primary antibody and β-actin primary antibody were purchased from Sigma.

[0050] 2. Experimental animals and treatment methods

[0051] Experimental animals: SPF grade male Kunming mice (18-22 g) were purchased from the Experimental Animal Center of Shandong University. Experimental animal production license number: SCXK (Lu) 2009-0001. Experimenta...

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Abstract

The invention provides application of allyl methyl trisulfide in the preparation of a medicine and/or a health product for preventing and/or treating drug-induced liver injury. Allyl methyl trisulfidecan effectively reduce death rate caused by APAP and inhibit rise of serum transaminase activity and increase of liver coefficient due to APAP, and can obviously mitigate liver injury caused by APAP.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the application of allylmethyl trisulfide in the preparation of products for preventing and treating drug-induced liver injury. Background technique [0002] Acetaminophen (APAP) is an antipyretic and analgesic drug widely used clinically. At therapeutic doses, APAP is well tolerated, can quickly and effectively relieve the discomfort of patients, and rarely causes serious side effects. It is an over-the-counter drug that is always available in families in most countries. However, overdose or long-term use of a single APAP-containing drug, or repeated use of similar drugs can lead to liver damage, cholestatic hepatitis, and severe cases can lead to hepatic coma or even death. Foreign epidemiological surveys show that excessive APAP is the primary cause of acute liver failure in European and American countries; domestic epidemiological surveys show that hepatitis B virus is the primary ca...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/095A61P1/16A23L33/105
CPCA23L33/105A23V2002/00A61K31/095A61P1/16A23V2200/30A23V2250/212
Inventor 曾涛郭芳芳张翠丽赵慧涓
Owner SHANDONG UNIV
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