Negative pressure transdermal dosing instrument and application method thereof

Abstract

The invention discloses a negative pressure transdermal dosing instrument and an application method thereof, and relates to the technical field of transdermal dosing. The negative pressure transdermaldosing instrument includes a dosing instrument box, a power interface, an external connection dosing end, the power interface is arranged on the dosing instrument box, and the external connection dosing end is connected to the dosing instrument box; and the negative pressure transdermal dosing instrument further includes a leakage protector, a vacuum display table, a time display table, a vacuumpump, a vacuum degree adjustment device, a time adjustment device, a control circuit board, a vacuum exhaust control valve and a vacuum outlet. A time relay is used for controlling and adjusting opening and closing of the vacuum pump and closing and opening of the vacuum exhaust control valve through a circuit under the condition of negative pressure, thus the magnitude of the negative pressure isadjusted, constant morphologic change of skin under the action of different vacuum degrees is achieved, pores and tissue gaps of the skin are constantly widened and narrowed to make the skin form a 'breathing' effect, and then drug can better enter the skin and be absorbed by human body.

Description

technical field [0001] The invention relates to the technical field of transdermal drug delivery, and more specifically relates to a negative pressure transdermal drug delivery device and a method for using the same. Background technique [0002] The concept of "transdermal technology" was first proposed by the United States in 1974. The so-called transdermal technology (transdermal therapeutic systems, TTS) is a new way of non-invasive drug delivery, which refers to drug delivery on the surface of the skin, so that the drug can pass through all layers of the skin. The method of entering the human body and circulatory system to produce systemic or local therapeutic effects is an important breakthrough in the traditional concept of skin medicine, and the research in this new field is very active at present. [0003] Compared with other drug delivery methods, the transdermal drug delivery technology has its unique advantages. The advantages are as follows: firstly, the transde...

AI Technical Summary

Problems solved by technology

Negative pressure in the negative pressure drug delivery technology is to make the skin and body tissues locally swell, and open the dermis, epidermis, capillaries and pores through negative pressure to open the pores and skin, so that the skin surface area increases and the skin tissue The gap increases, thereby reducing the barrier of drug transdermal, increasing the area of ​​the skin to absorb and infiltrate the drug, but the actual effect of the above methods is not ideal, and there are limitations in practical applications. Directly connecting the negative pressure to the skin is the Open the skin gap under negative pressure to allow the drug to enter the skin, but the skin is taut when it is in an open state under negative pressure, and the amount of drug entering is small. Another method is to apply positive pressure to the skin under negative pressure. Because the skin is also in a tense state under negative pressure, applying positive pressure under negative pressure is also not effective.

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