The application of the alkyd acid of Bacillus antler for the preparation of the medicine for reversing the drug resistance of ovarian cancer to paclitaxel

A drug resistance, ovarian cancer technology, applied in the field of medicine, can solve the problems of high recurrence rate and high mortality rate of this disease
CN109260187BInactive Publication Date: 2020-11-20普瑞赛森(山东)生物医学科技有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
普瑞赛森(山东)生物医学科技有限公司
Publication Date
2020-11-20
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a use of yew antler alkyd for reversing ovarian cancer resistance to paclitaxel. Ovarian cancer is one of the three major malignant tumors of female reproductive system, and the survival time of most patients with advanced ovarian cancer is less than 5 years. Clinical treatment of ovarian cancer usually uses cytoreductive surgery and follows by postoperative chemotherapy with platinum and paclitaxel. However, ovarian cancer cell resistance to chemotherapy drugs leads to high recurrence rate and mortality, so it becomes the bottleneck of clinical treatment. The inventiondiscloses that yew antler acid, yew antler alkyd and cedric acid can enhance the proliferation inhibition effect of Taxol on A2780 / Taxol cells in different degrees, improve the sensitivity of cells to Taxol, and can be developed as a medicine for reversing the resistance of ovarian cancer to taxol.
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Description

technical field

[0001] The invention belongs to the field of medicine and relates to the discovery of drugs for reversing drug resistance of ovarian cancer to paclitaxel. Background technique

[0002] Ovarian cancer is one of the three major malignant tumors of the female reproductive system, and the survival time of most advanced ovarian cancer patients is less than 5 years. The clinical treatment of ovarian cancer usually uses tumor cytoreductive surgery, supplemented by chemotherapy with platinum and paclitaxel after surgery. However, the drug resistance of ovarian cancer cells to chemotherapeutic drugs leads to a high recurrence rate and high mortality rate of the disease, which has become a bottleneck in clinical treatment. Contents of the invention

[0003] The purpose of the present invention is to provide a drug for reversing drug resistance of ovarian cancer to paclitaxel.

[0004] The present invention realizes through following technical scheme:

[0005] Appl...

Claims

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