A quick-acting hemostatic gauze for promoting wound healing and its preparation method and application

Abstract

The invention provides a quick-acting hemostatic yarn for promoting wound healing and its preparation method and application. The raw materials for the preparation of the quick-acting hemostatic yarn include the following components: 35-60 parts by weight of sodium carboxymethyl cellulose, 30-60 parts by weight of polyurethane elastomer 50 parts by weight, 5-20 parts by weight of n-octyl α-cyanoacrylate, 10-30 parts by weight of chitosan, 10-20 parts by weight of methyl p-hydroxybenzoate, 15-25 parts by weight of propyl p-hydroxybenzoate , 5-10 parts by weight of xanthan gum; wherein said chitosan is the mixture of lauroyl sulfate deacetyl chitosan and carboxymethyl chitosan; the quick-acting hemostatic yarn prepared by the present invention has better hemostatic effect and The antibacterial rate, and can also provide a suitable moist recovery environment for the wound, without sensitization to the skin.

Description

technical field [0001] The invention belongs to the field of medical gauze, and relates to a fast-acting hemostatic gauze for promoting wound healing, a preparation method and application thereof. Background technique [0002] Dressing refers to the auxiliary material used for the main material of the article. An important function of modern wound dressing is that it replaces the important function of damaged skin and works until the wound heals and the skin lesion heals; it can resist mechanical factors ( Such as dirt, collision, inflammation, etc.), resist pollution and chemical stimulation; prevent secondary infection; prevent dryness and loss of body fluid (electrolyte loss); prevent heat loss; environment. [0003] At present, although the commonly used medical antibacterial dressings have antibacterial properties, they have disadvantages such as unsatisfactory antibacterial effect, slow wound healing, poor biocompatibility, and ineffective prevention of wound infectio...

AI Technical Summary

Problems solved by technology

[0003] At present, although the commonly used medical antibacterial dressings have antibacterial properties, they have disadvantages such as unsatisfactory antibacterial effect, slow wound healing, poor biocompatibility, and ineffective prevention of wound infection.

[0004] CN104491919A discloses a propolis hemostatic gauze, which is characterized in that it is made of the following raw materials in parts by weight: propolis 6-8, carbomer 1-2, gelatin 6-8, sodium alginate 2-4, jojoba oil 0.3 -0.5, grape seed oil 0.1-0.2, hydroxyethyl cellulose 1-2, sodium carboxymethyl cellulose 2-4, D-panthenol 0.05-0.1, polysorbate 0.1-0.2, excipients 1-2, water 200-250; the hemostatic gauze prepared by this invention has better hemostatic effect, but its hemostatic effect and antibacterial and anti-inflammatory effect still need to be improved

[0005] CN107335089A discloses a modified hydrophilic polyurethane dressing and a preparation method thereof. The dressing comprises the following components: 20-40 parts of polyurethane, 25-40 parts of collagen, 5-10 parts of hyaluronic acid, 5-5 parts of chitosan 8 parts, 1-4 parts of egg white, 20-30 parts of sodium alginate, 1-4 parts of Cordyceps extract, 8-13 parts of silver nano solution, 10-20 parts of carboxymethyl cellulose, 12-18 parts of bamboo fiber, Acetyl cellulose sodium 12-20 parts; preparation method: weigh each component by weight; melt polyurethane, collagen, hyaluronic acid, chitosan, egg white and sodium alginate in a reaction kettle, reduce to 50 After -60°C, add the remaining raw materials, cool down and defoam to obtain the first mixture for later use; apply the first mixture on the colloid layer, and seal it after natural drying to obtain a modified hydrophilic polyurethane dressing; the dressing prepared by the invention has better Moisturizing effect and antibacterial effect, but its hemostatic performance needs to be improved

Preparation method: Weigh each component by weight; melt polyurethane, n-butyl α-cyanoacrylate, hyaluronic acid and carboxymethyl cellulose in a reaction kettle, add sodium alginate after complete melting, and keep warm ; Under the condition of constant stirring, slowly add the rest of the raw materials into the reaction kettle, and after being completely mixed, cool down and defoam; spread the mixture evenly on the base cloth, cool down, and cover the peeling layer on the coated colloid layer , that is; the polyurethane dressing prepared by the invention has the advantages of long moisturizing time and no irritation to the skin, but it does not mention its hemostatic effect and bactericidal performance

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