Uses of dental pulp stem cells in preparation of asthma treating drugs

A technology of dental pulp stem cells and therapeutic drugs, which is applied in the field of preparation of asthma treatment drugs by dental pulp stem cells, and can solve the problems such as that asthma cannot reach 50%.

Pending Publication Date: 2019-02-01
上海卡智生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It can be seen from the above data that the current treatment methods for bronchial asthma still have certain limitations, and the control rate of asthma cannot reach 50%, so there is an urgent need for a drug or treatment method that can effectively treat bronchial asthma

Method used

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  • Uses of dental pulp stem cells in preparation of asthma treating drugs
  • Uses of dental pulp stem cells in preparation of asthma treating drugs
  • Uses of dental pulp stem cells in preparation of asthma treating drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0071] Example 1 Dental pulp stem cells for the treatment of asthma

[0072] 1. Research content

[0073] 1) Construct a mouse asthma model and evaluate the mouse asthma model. Then the animal models were divided into a blank control group, an asthma control group, and a deciduous tooth pulp stem cell treatment group.

[0074] 2) Intervene with exfoliated deciduous tooth pulp stem cells (SHED), and observe the effects of SHED on the pulmonary inflammatory response and airway hyperresponsiveness of mice in each group: obtain lung tissue, alveolar lavage fluid, and peripheral serum, and use HE staining, ELISA, Flow cytometry analysis and other methods were used to analyze the changes of peripheral blood IgE levels, pulmonary inflammatory cell infiltration, alveolar lavage fluid inflammatory cells and cytokines in different groups.

[0075] 2. Experimental materials

[0076] 1) Experimental animals

[0077] Balb / c mice, female, 4-5 weeks old, SPF grade.

[0078] All animal h...

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Abstract

The invention relates to the field of biotechnology, particularly to uses of dental pulp stem cells in preparation of asthma treating drugs. According to the present invention, the test results provethe asthma treating effect of the dental pulp stem cell infusion, such that the optimal treating scheme is provided for the selection of stem cells for clinical application, and the basis is providedfor the preparation of the individual treatment scheme of stem cells.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to the use of dental pulp stem cells in the preparation of medicines for treating asthma. Background technique [0002] With the rapid economic development and industrialization process, as well as changes in people's lifestyles, the prevalence of bronchial asthma in my country is showing a rapid upward trend, and it has become one of the important chronic airway diseases that seriously endanger people's health. Asthma is a chronic airway inflammatory disease involving a variety of cells including eosinophils, mast cells, T lymphocytes, neutrophils, smooth muscle cells, airway epithelial cells, and cell components. Its clinical manifestations are recurrent symptoms such as wheezing, breath, chest tightness or coughing, which often occur or aggravate at night or in the early morning. As the course of the disease prolongs, it can lead to a series of changes in airway structure, that is, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/32A61K45/06A61P11/06
CPCA61K35/32A61K45/06A61P11/06
Inventor 屈玉兰白冲胡珍丽时冬辰韩颖赖亚丽曹婧
Owner 上海卡智生物技术有限公司
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