Polycyclic pyridone compound as well as pharmaceutical composition and application thereof
A technology of heterocyclic compounds and drugs, which is applied in the field of polycyclic pyridone compounds and their drug combinations and uses, and can solve problems such as drug resistance and the impact of therapeutic effectiveness
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[0033] The present invention will be described in further detail below through examples, but the present invention is not limited to these examples. The reagents and raw materials used in the examples of the present invention are all commercially available.
[0034]
[0035] Preparation of Compound 2
[0036]Under a nitrogen atmosphere, to a solution of compound 1 (10.0 g, 99.0 mmol) in THF (150 mL) was added 2.5 M n-butyllithium-hexane solution (39.6 mL, 99.0 mmol), and the mixture was stirred at -78 ° C for 2 Hour. A solution of allyl chloroformate (11.92 g, 99.0 mmol) in THF (40 mL) was added dropwise to the reaction mixture, stirred at -78°C for 2 hours, the reaction solution was quenched with saturated aqueous ammonium chloride solution, raised to room temperature, Extract with ethyl acetate. Wash with saturated brine, dry the organic layer with anhydrous magnesium sulfate, and distill off the solvent under reduced pressure to obtain compound 2 (11.87 g, yield 65%)....
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