Composition for preventing or treating mental disorder, containing lactobacillus sp. bacteria-derived vesicle

A Lactobacillus, a technology for mental disorders, used in compositions for improving or treating mental disorders, in the field of prevention

Active Publication Date: 2019-05-21
MD HEALTHCARE INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Although Lactobacillus plantarum is known to secrete factors that suppress depression in the brain, no vesicles secreted from Lactobacillus plantarum or Lactobacillus casei have been used to prevent or treat mental disorders such as stress, anxiety, post-traumatic stress disorder (PTSD) , panic disorder, depression, autism spectrum disorder, attention deficit hyperactivity disorder (ADHD), or schizophrenia

Method used

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  • Composition for preventing or treating mental disorder, containing lactobacillus sp. bacteria-derived vesicle
  • Composition for preventing or treating mental disorder, containing lactobacillus sp. bacteria-derived vesicle
  • Composition for preventing or treating mental disorder, containing lactobacillus sp. bacteria-derived vesicle

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] Example 1. Confirmation of anti-stress effect by vesicles derived from bacteria of the genus Lactobacillus

[0070] By experiments using mice, it was examined whether the occurrence of stress-induced depressive behavior was interrupted when nanovesicles derived from Lactobacillus plantarum were administered. For this, according to figure 1 In the experimental process shown, 7-week-old male C57BL / 6 mice were purchased and randomly divided into 4 groups, i.e. the normal mouse group (CON or CON+Veh) administered with normal saline (0.9% saline, 100 μl) for 14 days, A group of normal mice (CON+EV) administered nanovesicles (2 μg / mouse / 100 μl) in which saline (0.9% saline, 100 μl) was administered to mice exposed to restraint stress (RST) for 2 hours per day for A group for 14 days (RST+Veh), and a group in which nanovesicles (EV, 2ug / mouse / 100μl) were administered to mice exposed to restraint stress for two hours per day for 14 days (RST+EV) , for experimentation. Then, ...

Embodiment 2

[0074] Example 2. Confirmation of the anti-stress effect of vesicles derived from Lactobacillus plantarum

[0075] In addition to the results of Example 1, it was also evaluated whether depressive behavior induced by chronic stress could be restored by administration of nanovesicles derived from Lactobacillus plantarum. For this, as Figure 4 As shown in the figure, male C57BL / 6 mice aged 7 weeks were purchased and randomly divided into 5 groups, that is, the normal mouse group (CON or CON+Veh) administered with normal saline (0.9% saline, 100 μl) for 14 days, administered Normal mouse groups (CON+EV) of nanovesicles (2, 4 or 6 μg / mouse / 100 μl) in which saline (0.9% saline, 100 μl) were administered to mice exposed to chronic stress for 14 days Group (RST+Veh), wherein nanovesicles (EV, 2, 4 or 6ug / mouse / 100μl) were administered to mice exposed to chronic stress for 14 days (RST+EV), and wherein Imipramine (IMI, 20 mg / kg / day) was administered to mice exposed to chronic stres...

Embodiment 3

[0080] Example 3. Confirmation of antistress and antidepressant effects by nanovesicles derived from Lactobacillus casei

[0081] By experiments using mice, it was examined whether the occurrence of stress-induced depressive behavior was interrupted when Lactobacillus casei-derived nanovesicles were administered. For this, according to Figure 9 In the experimental process shown, 8-week-old male C57BL / 6 mice were purchased and randomly divided into 4 groups, that is, the normal mouse group (CON+Veh) administered with normal saline (0.9% saline, 100 μl) for 14 days, administered with nano Normal mouse group (CON+Lac) of vesicles (11 μg / mouse / 100 μl) in which saline (0.9% saline, 100 μl) was administered to mice exposed to restraint stress (RST) for 2 hours per day for 14 days group (RST+Veh), and in which nanovesicles (EV, 11ug / mouse / 100μl) were administered to mice exposed to restraint stress for 2 hours per day for 14 days (RST+Lac), and conduct experiment. Then, the U-BOX...

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Abstract

The present invention relates to a composition for preventing, improving or treating a mental disorder, the composition containing a Lactobacillus sp. bacteria-derived vesicle as an active ingredient.The present inventors have confirmed that, when a Lactobacillus sp. bacteria-derived vesicle is administered to a stress and depression animal model, resistance to stress efficiently increases, and an effect of treating chronically persisting long-term depression behavior is exhibited, and thus the Lactobacillus sp. bacteria-derived vesicle, according to the present invention, is expected to be capable of being usefully employed in developing a medicine or a functional health food, etc., for preventing, reducing the symptoms of or treating a mental disorder such as stress, anxiety disorder, post-traumatic stress disorder, panic disorder, depression, autism spectrum disorder, attention deficit hyperactivity disorder and schizophrenia.

Description

technical field [0001] The present invention relates to a composition for preventing, improving or treating mental diseases, comprising vesicles derived from bacteria of the genus Lactobacillus as an active ingredient. Background technique [0002] Depression, a disorder in which negative emotions develop due to changes in brain function that control emotions, affects more than 300 million people worldwide. In addition, according to the five-year analysis data of depression from 2005 to 2009 by Korea Health Insurance Evaluation and Evaluation Service, patients diagnosed with depression and total medical expenses increased by an average of 4% and 10.4% per year, respectively. The number of patients diagnosed with depression increased from 435,000 in 2005 to 500,300 in 2009, indicating an average annual increase in the number of patients of about 18,000. In particular, the increase was the highest for those aged seventy or over. [0003] Although various studies have been at...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/747A23L33/135A61K9/00
CPCA23L33/135A61K35/747A61P25/22A61P25/18A61P25/24A61K9/0073A23V2002/00A23V2200/322A61K9/127
Inventor 金润根韩平林崔主理
Owner MD HEALTHCARE INC
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