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Preparation method of Rubus delavayi Franch. plant extracts and pharmaceutical composition thereof as well as application of Rubus delavayi Franch. plant extracts to anti-trichinella spiralis

A technology of rubus trilobites and extracts, which is applied in the directions of drug combinations, pharmaceutical formulations, plant raw materials, etc., can solve problems such as no rubus trilobites extracts and the like, and achieve the effect of good anti-trichinella activity.

Inactive Publication Date: 2019-05-28
DALI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there is no preparation method of the extract of Rubus trifoliata at home and abroad and the drug combination with the extract as the active ingredient, and its anti-trichinosis ( Trichinella spiralis ) reports on the application of

Method used

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  • Preparation method of Rubus delavayi Franch. plant extracts and pharmaceutical composition thereof as well as application of Rubus delavayi Franch. plant extracts to anti-trichinella spiralis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] The preparation of Rubus trifoliata extract of the present invention:

[0020] The whole plant of Rubus trifoliata was dried naturally, crushed to 30 mesh, and washed with 75% ethanol at 95 o Under the condition of C, reflux extraction was carried out 3 times, each time for 2 h, the extracts were combined, and the extracts were concentrated under reduced pressure to obtain the extract.

Embodiment 2

[0022] Anti-trichinella activity detection of the extract of the present invention:

[0023] The Kunming mice were divided into random groups, 5 mice in each group, and 200 Trichinella spiralis were orally infected. The corresponding drugs were given 3 hours after infection and continued for 7 days. The positive control group was given albendazole, and the negative control group was given corresponding volume of normal saline. The small intestine was dissected the next day after the last administration, and cut into 1 cm segments. After incubation in normal saline at 37 °C for 3 h, the adult worms were collected and counted to calculate the worm reduction rate. The calculation formula is as follows:

[0024] Insect reduction rate (%) = [(average number of insects in the control group - average number of insects in the treatment group) / average number of insects in the control group] × 100%

[0025] Activity data are shown in Table 1.

[0026] Table 1 Anti-trichinella activi...

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Abstract

The invention relates to a preparation method of Rubus delavayi Franch. plant extracts and a pharmaceutical composition thereof as well as application of the Rubus delavayi Franch. plant extracts to anti-trichinella spiralis, and belongs to the field of traditional Chinese medicines and natural medicines. The preparation method of a anti-trichinella spiralis medicine made of the extract as an active ingredient comprises the following steps: taking and drying a whole plant of the Rubus delavayi Franch. plant and pauperizing the whole plant of the Rubus delavayi Franch. plant to reach 20 meshesto 30 meshes; performing extraction by using an organic solvent ( petroleum ether or chloroform or ethyl acetate or acetone or methanol or ethanol) or water. The invention also discloses application of the Rubus delavayi Franch. plant to preparation of an anti-trichinella spiralis agent; 0.01g to 30g of the plant is applied to a substrate or one group, and can be optionally combined with a carrierand / or a medium, so that the plant has higher anti-trichinella spiralis activity. The preparation method of the Rubus delavayi Franch. plant extracts and the pharmaceutical composition thereof as well as application of the Rubus delavayi Franch. plant extracts to the anti-trichinella spiralis disclosed by the invention have the advantages that the adaptability of Rubus delavayi Franch. medicinalmaterials is widened, and a medicinal value of the Rubus delavayi Franch. medicinal materials is improved.

Description

Technical field: [0001] The invention belongs to the field of traditional Chinese medicine and natural medicine pharmacy, and in particular relates to a preparation method of an extract of Rubus trifoliata, a drug combination using the extract as an active ingredient, and its application in an anti-trichinella agent. technical background: [0002] Rubus trefoil ( Rubus delavayi Franch.) is the genus Rubus (Rosaceae) of the family Rosaceae ( Rubus ) plants, perennial erect dwarf shrubs, 0.3-1 meter high; branches reddish brown, cylindrical, glabrous, with small prickles, 3 leaflets, lanceolate to narrowly lanceolate; produced in most parts of Yunnan; born in Under the miscellaneous forests of mountains at an altitude of 2000-3400 meters. Its leaves and root bark contain tannins, which can be used to extract tannins. Rubus trifoliata is sweet, slightly sour, and flat in nature; it has the effects of clearing away heat and detoxification, stopping dysentery, and repelling ...

Claims

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Application Information

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IPC IPC(8): A61K36/73A61P33/10
Inventor 姜北肖朝江王敏罗晓磊董相李海峰
Owner DALI UNIV
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