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Traditional Chinese medicine composition with effect of inhibiting activity of monoamine oxidase A and application thereof

A technology of monoamine oxidase and composition, which is applied in the direction of drug combination, medical preparation containing active ingredients, pharmaceutical formula, etc., to achieve a significant synergistic effect

Inactive Publication Date: 2019-06-07
SICHUAN ACAD OF CHINESE MEDICINE SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Only the combined use of Angelica and Chuanxiong as an effective MAO-A inhibitor has not been reported in the literature

Method used

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  • Traditional Chinese medicine composition with effect of inhibiting activity of monoamine oxidase A and application thereof
  • Traditional Chinese medicine composition with effect of inhibiting activity of monoamine oxidase A and application thereof
  • Traditional Chinese medicine composition with effect of inhibiting activity of monoamine oxidase A and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The medicinal material of Rhizoma Chuanxiong was taken, crushed, and passed through a 100-mesh sieve; the medicinal material of Angelica sinensis was obtained, crushed, and passed through a 100-mesh sieve; the Rhizoma Chuanxiong powder and the Angelica sinensis powder were mixed according to the mass ratio of 1:2, and packaged separately to obtain a monoamine oxidase A inhibitor.

Embodiment 2

[0025] Take the medicinal material of Chuanxiong, crush it, add 8 times the amount of 70% ethanol, soak overnight, heat and reflux for extraction 3 times, combine the filtrate, recover the alcohol, concentrate, and dry to obtain the ethanol solution extract of Rhizoma Chuanxiong; take the medicinal material of Angelica sinensis, crush it, add 8 times Measure 70% ethanol, soak overnight, heat and reflux to extract 3 times, combine the filtrate, recover alcohol, concentrate, dry, and obtain the ethanol solution extract of Angelica sinensis; :0.2 Mixed evenly to obtain monoamine oxidase A inhibitor, the mass content of ferulic acid is 1.24%, and the mass content of ligustilide is 16.1%.

Embodiment 3

[0027] Ligusticum chuanxiong medicinal material was taken, crushed, added 8 times the amount of distilled water, soaked overnight, extracted by heating, and the volatile oil was collected by condensation to obtain volatile oil of chuanxiong; the extract product of angelica sinensis was purchased in the market, and the volatile oil of angelica sinensis was obtained by water distillation. The volatile oil of Rhizoma Chuanxiong and the volatile oil of Angelica sinensis were separated and purified by molecular distillation technology, and then mixed uniformly according to the mass ratio of 1:5 to obtain the monoamine oxidase A inhibitor, and the mass content of ligustilide was 8.0%.

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Abstract

The invention discloses a traditional Chinese medicine composition with an effect of inhibiting the activity of monoamine oxidase A and application thereof. The traditional Chinese medicine composition is prepared together from a composition of a Chinese angelica root raw medicinal material or extract thereof and a chuanxiong rhizome raw medicinal material or extract thereof, serving as an effective medicinal ingredient, with acceptable auxiliary additives in medicinal materials. The extract can be an alcohol solution extract, an aqueous solution extract or volatile oil. The traditional Chinese medicine composition can be independently used as a medicine for inhibiting the activity of monoamine oxidase A or used as a medicinal ingredient for inhibiting the activity of monoamine oxidase A to combine with other available medicinal ingredients in the field of medicines. The chuanxiong rhizomes and Chinese angelica roots respectively have the effect of inhibiting human monoamine oxidase A,and are combined to serve as the inhibitor of monoamine oxidase A due to the remarkable synergistic effect.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition capable of inhibiting the activity of monoamine oxidase A and its application. More specifically, the invention relates to a traditional Chinese medicine composition capable of inhibiting the activity of monoamine oxidase A, which is composed of angelica and chuanxiong as active ingredients in a certain proportion. Background technique [0002] Angelica and Chuanxiong are both traditional Chinese medicines. Angelica sinensis is the dried root of Angelica sinensis (Oliv.) Diels, an umbrella plant. The volatile oil is an important part of its pharmacological effects, and has a wide range of pharmacological activities in the cardiovascular system, respiratory system, digestive system and tumors. Chuanxiong is the rhizome of Ligusticum chuanxiongHort., an Umbelliferae plant, and its volatile oil has significant curative effects in improving microcirculation and antithrombotic. Clinically,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/236A61P25/22
Inventor 谭正怀熊静悦唐大轩张秀刘琪
Owner SICHUAN ACAD OF CHINESE MEDICINE SCI
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