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Application of MBL in preparing drug for preventing or treating obesity and method for screening drug for preventing or treating obesity

A drug, technology for obesity, applied in the field of biotechnology and medicine

Active Publication Date: 2019-07-26
XINXIANG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no information about the influence of MBL on energy metabolism. Whether MBL is associated with obesity or whether it regulates the formation of fat has not been reported.

Method used

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  • Application of MBL in preparing drug for preventing or treating obesity and method for screening drug for preventing or treating obesity
  • Application of MBL in preparing drug for preventing or treating obesity and method for screening drug for preventing or treating obesity
  • Application of MBL in preparing drug for preventing or treating obesity and method for screening drug for preventing or treating obesity

Examples

Experimental program
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Effect test

Embodiment 1

[0039] In this embodiment, the mannose-binding lectin can be used to prepare a drug for inhibiting fat cell volume increase.

Embodiment 2

[0041] In this embodiment, the mannose-binding lectin can be used to prepare drugs for preventing or treating disorders of glucose metabolism or lipid metabolism.

Embodiment 3

[0043] In this embodiment, the mannose-binding lectin can be used to prepare a drug for inhibiting the adipogenic differentiation of 3T3-L1 preadipocytes.

[0044] Example 1 of the method for screening drugs for the prevention or treatment of obesity

[0045] The method for screening drugs for preventing or treating obesity in this example specifically includes: using gene editing technology to obtain mannose-binding lectin gene-deficient mice, and administering an appropriate amount to mannose-binding lectin gene-deficient mice with obesity symptoms The drugs to be screened are analyzed to analyze the changes in the obesity indicators of mannose-binding lectin gene-deficient mice, and the drugs that can alleviate the obesity symptoms of mannose-binding lectin gene-deficient mice are selected. The obesity index of the mannose-binding lectin gene-deficient mice is an index of body fat content, glucose metabolism, lipid metabolism and / or adipogenic differentiation.

[0046] Exa...

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Abstract

The invention relates to application of MBL in preparing a drug for preventing or treating obesity and a method for screening the drug for preventing or treating the obesity, and belongs to the technical field of biotechnology and medicine. The MBL levels of normal control serum and obese patient serum are studied, and the MBL level of the obese patient serum is obviously less than the normal control serum. The gene editing technology is utilized to obtain mannose-binding lectin gene-deficient mice and find that MBL gene knockout significantly aggravates the blood glucose metabolism disorder in obese mice, and the fat cell volume is increased. An experiment of MBL inhibiting adipocyte differentiation shows that MBL can inhibit the adipocyte differentiation by down regulating the adipogenicdifferentiation related genes C / EBP alpha and PPAR gamma. From above, the MBL and the obesity have a close relationship. Therefore, the mannose-binding lectin can be used for preparing the drug for preventing or treating the obesity and preparing the drug for inhibiting the adipogenic differentiation of 3T3-L1 preadipocytes.

Description

technical field [0001] The invention relates to the application of MBL in preparing the medicine for preventing or treating obesity and the method for screening the medicine for preventing or treating obesity, belonging to the fields of biotechnology and medical technology. Background technique [0002] A series of metabolic disorders caused by obesity, such as type 2 diabetes, non-alcoholic fatty liver, cardiovascular and cerebrovascular diseases, etc., currently lack effective methods to curb and treat obesity. Adipose tissue is generated through the differentiation of adipose-derived mesenchymal stem cells (MSCs). The increase in the number and volume of fat cells will cause the increase of adipose tissue, which will lead to obesity. The increased number of adipocytes is caused by excessive proliferation and differentiation of preadipocytes, while the increased volume of adipocytes is caused by increased accumulation of intracellular triglycerides. Because obesity is ca...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/17A61P3/04
CPCA61K38/1732A61P3/04
Inventor 王明永王凡平张伟杨泳慧吴敏娜杨婧文
Owner XINXIANG MEDICAL UNIV
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