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Combined application of CNS (central nerves system) inhibitor and opioids in endoscopy

A technology for opioid substances and gastroscopy, which is applied in the direction of drug combinations, anesthetics, medical preparations containing active ingredients, etc.

Inactive Publication Date: 2019-09-13
JIANGSU HENGRUI MEDICINE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the combined application of opioids and sedative drugs still has adverse reactions such as hypotension and respiratory depression. Therefore, the rational selection of opioids and the grasp of the dosage are the key to the safe implementation of endoscopy under sedation

Method used

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  • Combined application of CNS (central nerves system) inhibitor and opioids in endoscopy
  • Combined application of CNS (central nerves system) inhibitor and opioids in endoscopy
  • Combined application of CNS (central nerves system) inhibitor and opioids in endoscopy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Example 1: Clinical research on remimazolam combined with fentanyl for gastroscopy

[0039] 1. Test drugs

[0040] Remimazolam tosylate for injection, the specification is 36mg / branch (calculated as free base), when in use, add 36ml of 0.9% normal saline to each cartridge, and the final configuration is 36ml of injection solution with a concentration of 1mg / ml;

[0041] Commercially available propofol injection;

[0042] Commercially available fentanyl injection.

[0043] 2. Inclusion criteria

[0044] 1) Age 18-60 years old, gender is not limited;

[0045] 2) Patients receiving routine gastroscopy diagnosis and treatment;

[0046] 3) The ASA score is grade I or grade II;

[0047] 4) 18kg / m 2 2 .

[0048] 3. Research groups

[0049] The remimazolam tosylate for injection group was the experimental group, and the propofol group was the control group.

[0050] 4. Test method

[0051] Complete routine preparations before gastroscopy (generally fasting for at leas...

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Abstract

The invention relates to combined application of a CNS (central nerves system) inhibitor and opioids in endoscopy, in particular to application of the CNS inhibitor and the opioids in preparation of drugs for calming and / or anesthesia in gastroscopy. The CNS inhibitor is remimazolam or pharmaceutical salts thereof, and the opioids are selected from morphine, codeine, thebaine, sufentanil, carfentanil, fentanyl, lofentanil, alfentanil, ohmefentanyl, remifentanil and the like.

Description

technical field [0001] The present invention relates to the use of a CNS depressant in combination with an opioid for sedation and / or anesthesia in endoscopy. Background technique [0002] Digestive endoscopic examinations such as gastroscopy and colonoscopy are often difficult for patients to cooperate and leave an unpleasant impression on patients. The use of sedative drugs can improve this situation, making such examinations go more smoothly and reducing the pain of patients. At present, in clinical practice, midazolam and propofol are commonly used as anesthesia and sedatives for outpatient operations such as gastrointestinal endoscopy. , but there are some safety issues that cannot be ignored, especially for the growing elderly population. [0003] Remimazolam, chemical name: 3-[(4s)-8-bromo-1-methyl-6-(2-pyridyl)-4H-imidazole[1,2-a][1,4 ] benzodiazepines -4-base] propionic acid methyl ester, structural formula is as shown in formula (I). EP1183243A reports that th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/06A61K31/5517A61P25/04A61P23/00A61P25/20A61K31/4468
CPCA61K31/4468A61K31/5517A61K45/06A61P23/00A61P25/04A61P25/20A61K2300/00
Inventor 刘惠龙曹永
Owner JIANGSU HENGRUI MEDICINE CO LTD
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