Protein phosphorylation site recognition method, system and device and storage medium

Abstract

The invention discloses a protein phosphorylation site identification method, system and device and a storage medium. The method comprises the following steps: acquiring an amino acid sequence fragment of a protein phosphorylation site to be identified; performing logic operation on binary codes of amino acids in the amino acid sequence fragment to obtain logic binary feature vectors of the aminoacid sequence fragment; performing kernel principal component analysis on the logic binary feature vector according to a preset kernel function to obtain a kernel principal component logic binary feature vector; and inputting the kernel principal component logic binary feature vector into a random forest model for processing to obtain an identification result of the protein phosphorylation site. Based on theoretical calculation of the random forest model, the method can achieve the quick and accurate recognition of the information of a large number of protein phosphorylation sites, is low in cost, facilitates the development of phosphorylation mechanism and phosphorylation and disease relation research, and is widely applied to the field of protein phosphorylation site recognition.

Description

technical field [0001] The invention relates to the field of protein phosphorylation site recognition, in particular to a method, system, device and storage medium for protein phosphorylation site recognition. Background technique [0002] Protein is the embodiment and executor of the biological function of living organisms. The protein after gene expression is called precursor protein, which is usually inactive and requires a series of processing and modification to become a protein with certain biological functions. Protein phosphorylation refers to a series of reaction types that transfer the phosphate group at the end of adenosine triphosphate to a specific amino group of a substrate protein under the action of protein kinase catalysis. It is the most common modification of protein post-translational processing known so far. Types of. Studies have shown that protein phosphorylation plays an important role in the processes of cell proliferation, development, differentiat...

AI Technical Summary

Problems solved by technology

However, only a very small amount of protein phosphorylation site information has been identified, which greatly hinders the study of protein phosphorylation mechanism

And experimental methods to identify phosphorylation sites are usually time-consuming, labor-intensive, and expensive

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