A Human Ewing Sarcoma Cell Line

Abstract

The present invention discloses a human Ewing sarcoma cell line, named as human drug-resistant Ewing sarcoma cell SGH-01, which was deposited in the China Center for Type Culture Collection (CCTCC) on October 18, 2018, and the deposit number is CCTCC NO: C2018222. The donor of the cell line is a patient with clinically drug-resistant Ewing sarcoma, the cell line has doxorubicin resistance, the ability to form subcutaneous tumors in nude mice, and the ability to form tumors in situ of the tibia, and the in situ tumor of the tibia in nude mice has lung metastasis. ability. This cell line can become the experimental material for researchers to conduct in-depth study of Ewing sarcoma drug resistance and metastasis mechanism and to find / evaluate treatment options.

Description

technical field [0001] The invention relates to a cell line, in particular to a human Ewing sarcoma cell line. Background technique [0002] Ewing's sarcoma (ES) is a poorly differentiated malignant tumor of small round cells, which accounts for 6% to 8% of all primary bone tumors, and is the most common malignant primary bone tumor in children and adolescents. The male-to-female ratio is about (2.0-2.5): 1. The whole body can be affected, but it is more common in the long bones of the limbs, such as: femur, humerus, and tibia, followed by flat bones, such as the scapula. The clinical manifestation is that a huge soft tissue mass appears in the affected area of ​​young patients, often accompanied by pain and swelling, as well as symptoms such as fever, anemia and weight loss. Lung is the most common metastatic site, followed by bone in other parts. Most patients may already have micrometastases when they see a doctor. [0003] Ewing sarcoma has a high degree of malignancy,...

AI Technical Summary

Problems solved by technology

[0005] Once Ewing sarcoma is resistant to first-line chemotherapy, other regimens will hardly have a good therapeutic effect. There is no drug-resistant Ewing sarcoma cell line

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