Application of Tinleaf vine and its extract in the preparation of medicines for treating and/or preventing alcoholic liver injury

A technology for alcohol-induced liver injury and tinea vine, which is applied in the field of drug application, can solve the problems of tin ye vine and its extract, which can restore the protein synthesis function, increase the albumin content, and inhibit the production of inflammatory factors. Effect

Active Publication Date: 2022-03-22
GUANGXI UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is no report on the application of safflower and its extracts in the preparation of drugs for the treatment and / or prevention of alcoholic liver injury

Method used

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  • Application of Tinleaf vine and its extract in the preparation of medicines for treating and/or preventing alcoholic liver injury
  • Application of Tinleaf vine and its extract in the preparation of medicines for treating and/or preventing alcoholic liver injury
  • Application of Tinleaf vine and its extract in the preparation of medicines for treating and/or preventing alcoholic liver injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] The preparation of embodiment 1 sycamore water extract

[0040] Tin leaf vine was collected in Wuming Gaofeng Forest Farm, Guangxi, and was identified as the stem of Tetracera asiatica (Lour.) Hoogland by Associate Professor Teng Jianbei of Guangxi University of Traditional Chinese Medicine. Take 200g of pulverized vine powder, add 5000mL of pure water each time, decoct at 100°C for 1 hour, repeat 3 times, combine the extracts obtained 3 times, concentrate into water extract extract, make each 1g of water extract The crude drug content in the ointment is 7.0771g.

Embodiment 2

[0041] The preparation of embodiment 2 tin yetogen alcohol extract

[0042] Tin leaf vine was collected in Wuming Gaofeng Forest Farm, Guangxi, and was identified as the stem of Tetracera asiatica (Lour.) Hoogland by Associate Professor Teng Jianbei of Guangxi University of Traditional Chinese Medicine. Take 100 g of the pulverized vine medicinal powder, add 2500 mL each time, 50% ethanol, reflux extraction in a water bath at 80° C. for 1 h, repeat 3 times, combine the obtained extracts for 3 times, concentrate to obtain the ethanol extract of vine vine, and make 1g of alcohol extract contains 6.9638g of crude drug.

Embodiment 3

[0043] The preparation of embodiment 3 vine ethyl acetate extract, n-butanol extract

[0044] Get the alcohol extract extract obtained in Example 2, disperse it in 50% ethanol, and use ethyl acetate to continuously extract 15 times, each 50mL, and the extracts are combined to obtain the extract of the vine ethyl acetate extract; Continuously extract 15 times with n-butanol, 50 mL each time, and combine the extracts to obtain the extract of n-butanol extract of Cinnamomum chinensis. Concentrate at 80 DEG C subsequently, make the crude drug content of 1g ethyl acetate extract extract be 52.0833g, make the crude drug content of 1g n-butanol extract extract be 41.6667g.

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Abstract

The invention relates to the application field of medicines, in particular to the application of sycamore and its extracts in the preparation of medicines for treating and / or preventing alcoholic liver damage. The extract of the vine of the present invention is selected from any one of the following or a mixture of more than one: the water extract of the vine, the alcohol extract of the vine, the ethyl acetate extract of the vine, the n-butanol of the vine Extract. The Tin Leaf Extract provided by the invention can significantly increase the serum albumin content of alcoholic liver injury mice, and improve the ability of the liver to synthesize albumin by repairing the endoplasmic reticulum, Golgi apparatus, ribosomes, etc. of damaged cells, thereby Provides protection to the liver.

Description

technical field [0001] The invention relates to the application field of medicines, in particular to the application of sycamore and its extracts in the preparation of medicines for treating and / or preventing alcoholic liver damage. Background technique [0002] Tin leaf vine is the root of Tetracera asiatica (Lour.) Hoogland. It is cool in nature, bitter in taste, has the functions of restraining diarrhea, reducing swelling and relieving pain. Commonly used in the treatment of diarrhea, dysentery, proctoptosis and other diseases. Its medicinal materials are rich in tannins, flavonoids, terpenoids and other biologically active ingredients, which have obvious antibacterial, anti-inflammatory, anti-tumor activities [State Administration of Traditional Chinese Medicine Chinese Materia Medica Editorial Committee. Zhonghua Materia Medica [M ]. Volume 3. Shanghai: Shanghai Science and Technology Press, 1999: 510-511.]. Tin leaf vine is rich in medicinal resources, and it is pro...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/185A61P1/16
CPCA61K36/185A61P1/16
Inventor 笪舫芳
Owner GUANGXI UNIV OF CHINESE MEDICINE
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