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Composition containing trisubstituted phosphine oxide and oxetanone derivative and application thereof

A technology of oxetanone and phosphine oxides, applied in the field of medicine, can solve the problem that there is no synergistic antibacterial effect of trisubstituted phosphine oxides and oxetanone derivatives

Inactive Publication Date: 2020-02-21
ZHONGSHAN WANHAN PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In the prior art, there is no technical teaching on the synergistic antibacterial effect of trisubstituted phosphine oxides and oxetanone derivatives

Method used

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  • Composition containing trisubstituted phosphine oxide and oxetanone derivative and application thereof
  • Composition containing trisubstituted phosphine oxide and oxetanone derivative and application thereof
  • Composition containing trisubstituted phosphine oxide and oxetanone derivative and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0105] Example 1 Preparation of an oral solid preparation containing a mixture of trisubstituted phosphine oxides and oxetanone derivatives

[0106] Prescription (1500 unit dose)

[0107]

[0108] Preparation

[0109] Take the prescribed amount of MIX (PX-OY) and auxiliary materials, and pass through a 100-mesh sieve. Take MIX (PX-OY), lactose, microcrystalline cellulose, crospovidone and starch and fully mix; take the prescribed amount of hypromellose, and prepare it into a product with a concentration of 10% based on hypromellose Solution, adjust the pH to 3.0-4.0 with lactic acid, add to the above-mentioned mixed material to make a soft material, granulate with a 16-mesh sieve, and dry at 80°C for 3-4 hours. Use a 16-mesh sieve to sieve the granules, add the prescribed amount of micropowder silica gel and magnesium stearate, mix well, fill the capsules, and obtain capsules;

[0110] Take the prescribed amount of MIX (PX-OY) and auxiliary materials, and pass through a...

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Abstract

The invention provides a composition containing a trisubstituted phosphine oxide and an oxetanone derivative. The specific definitions of the trisubstituted phosphine oxide and the oxetanone derivative are shown in the specification. The composition provided by the invention can generate the synergistic bacteriostatic effect (combined medication index CI is less than 1)) on various bacteria such as corynebacterium acidovorans and the like.

Description

technical field [0001] The invention belongs to the technical field of medicine, and specifically relates to a composition containing a mixture of trisubstituted phosphine oxide and oxetanone derivatives and its application. Background technique [0002] Nosocomial infection is an important issue affecting the quality of hospital care. With the continuous development and progress of modern medical technology, antibacterial drugs are widely used, and the drug-resistant strains of clinical pathogens are increasing. Therefore, improving the antibacterial activity of existing drugs will help to improve the therapeutic effect of patients with bacterial infections. [0003] Wei Wei of Guangdong University of Technology's master's thesis "Synthesis and Performance Research of Chlorine Ball Grafted Quaternary Ammonium Quaternary Phosphonium Solid Fungicide" disclosed that various quaternary phosphonium salt compounds have certain antibacterial effects. It is found that trisubstitu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/662A61K31/337A61K36/48A61K36/746A61K36/13A61K36/79A61K36/57A61P31/04
CPCA61K31/337A61K31/662A61K36/13A61K36/48A61K36/57A61K36/746A61K36/79A61P31/04A61K2300/00
Inventor 向飞杜志博杨衍秋苏海娟彭韪
Owner ZHONGSHAN WANHAN PHARM CO LTD
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