14 results about "Butylone" patented technology

This invention relates to a method for synthesizing squaric acid, the method comprising the following steps: (1) reacting alkyl vinyl ether, trichloroacetyl chloride, and zinc to obtain 2,2-dichloro-3-alkoxycyclobutanone; (2) subjecting 2,2-dichloro-3-alkoxycyclobutanone to chlorination with chlorine to obtain 2,2,4,4-tetrachloro-3-alkoxycyclobutanone; (3) subjecting 2,2,4,4-tetrachloro-3-alkoxycyclobutanone to elimination reaction with a base to obtain 2,4,4-trichloro-3-alkoxycyclobuten-1-one; and (4) subjecting 2,4,4-trichloro-3-alkoxycyclobuten-1-one to hydrolysis to obtain the squaric acid. The synthesis method provided by this invention avoids the use of the prohibited raw material perchloro-1,3-butadiene and has lower energy consumption, meeting the needs of green and clean production.

The invention discloses a peptide simulant and a preparation method thereof, 3-oxetanone and 3-methyl-1-nitrobutane are used as raw materials, and all reactions are carried out to obtain a target product. The peptide simulant is novel in structure and has potential biological activity, adopted protecting groups and functional groups are good in compatibility, and follow-up structural modification is facilitated; the designed synthesis route is simple, the reaction condition is mild, and amplification is easy; the yield of each step is high, and the product is easy to purify.

This invention discloses a benzamide / benzenesulfonamide compound containing an aryl butanone structure, its preparation method, and its application, belonging to the field of medicinal chemistry. The structure of the benzamide compound containing the aryl butanone structure is as follows: R1 is hydrogen, halogen, alkyl, or alkoxy; R2 is tert-butyl, tert-pentyl, tert-octyl, adamantyl, or α,α-dimethylbenzyl; R3 is hydrogen, halogen, alkyl, alkoxy, fused ring, or aryl; R4 is hydrogen, alkyl, or aryl. The structure of the benzenesulfonamide compound containing the aryl butanone structure is as follows: R1 is hydrogen, halogen, or alkyl; R2 is tert-butyl, tert-pentyl, or tert-octyl; R3 is hydrogen, halogen, alkyl, or fused ring. The advantages of this invention are that some of the prepared compounds exhibit strong inhibitory effects on MCF-7 and HCT-116, and can be used as lead compounds for the subsequent preparation and development of antitumor drugs.

The present disclosure is directed, in general, to synthesizing optionally substituted 2-dicyanomethylene-3-cyano-4-methyl-5-phenyl-5-perfluoromethyl-2,5-dihydrofuran comprising (i) reacting tributyl (1-ethoxyvinyl) tin with n-butyllithium at a temperature of between −30° C. and 10° C. to produce a first reaction product; (ii) reacting the first reaction product with 2,2,2-trifuoroacetophenone to produce a second reaction product: (iii) quenching the second reaction product with an acid to produce 3-hydroxy-3-phenyl-4,4,4-trifluoro-2-butanone; and (iv) reacting the 3-hydroxy-3-phenyl-4,4,4-trifluoro-2-butanone with malononitrile in the presence of base to produce 2-dicyanomethylene-3-cyano-4-methyl-5-phenyl-5-perfluoromethyl-2,5-dihydrofuran.

The present invention relates to a method for producing enantiomerically enriched cyclobutylamine of formula (I) from alpha-tert-cyclobutanone and reacting said enantiomerically enriched cyclobutylamine to obtain enantiomerically enriched cyclobutyramide. Such compounds are useful intermediates in the synthesis of microbicidal thiazole compounds. (I)

The invention relates to the technical field of drug synthesis equipment, in particular to an olmesartan medoxomil phosgene substitution type acylation reaction system, which comprises a reaction container, a reaction kettle, a reaction kettle and a control system, the triphosgene adding device is connected with the reaction container and is used for quantitatively adding triphosgene into the reaction container; the solvent conveying unit is connected with the reaction container and is used for pumping a solvent into the reaction container; the mixed solution feeding unit is connected with the reaction container and is used for slowly adding a mixed solution of 3-hydroxybutanone and a solvent into the reaction container; the temperature control module is connected with the reaction container and is used for accurately controlling the reaction temperature in the reaction container; and the pH adjusting and quenching unit is connected with the reaction container. According to the invention, the triphosgene adding device and the closed system are adopted to completely replace highly toxic gas phosgene, so that major potential safety hazards in the production, storage and transportation processes are fundamentally solved.

The application provides a high-transparency low-shrinkage TPU film and a preparation method thereof. The preparation raw material of the high-transparency low-shrinkage TPU film comprises the following components in parts by weight: 100 parts by weight of TPU particles, 30-60 parts by weight of polycarbonate, 0.1-0.5 parts by weight of (4-hydroxycyclohexyl)methyl) tert-butyl carbamate, 0.5-1 parts by weight of 1-(2,4-dihydroxy-3-trifluoromethyl-phenyl)-3-methyl-butan-1-one and 1-3 parts by weight of an antioxidant. The shrinkage of the TPU film is as low as 0.1% or below, the TPU film has good transparency, the light transmittance is 98.5% or above, the mechanical strength is high, and the TPU film is suitable for multiple fields such as automobiles, household appliances, electrical instruments, mechanical industry and the like.

The application provides a special sealant for simulation cake shaping and a preparation method thereof, and relates to the technical field of adhesives.The raw material composition of the sealant comprises alpha, omega-dihydroxypolydimethylsiloxane, methyltributanone oxime silyl, a catalyst, a composite regulator, edible-grade white oil, gamma-aminopropyltriethoxysilane, nano calcium carbonate loaded blocked isocyanate and deionized water.The catalyst is dibutyltin dilaurate; and the composite regulator is a mixture of modified nano silicon dioxide and an antioxidant.The special sealant for simulation cake shaping prepared by the application has the advantages of short setting time, excellent aging resistance and environmental protection.

This invention belongs to the field of pharmaceutical chemistry, specifically relating to a method for preparing substituted heterocyclic fused carboline compounds. In this method, the compound of formula 3a, 4-iodo-4'-fluorophenylbutanone, and a base are reacted at low temperature, resulting in a high yield and purity of the lumepirobenone base. The method of this invention can effectively improve the quality of the finished product and is more suitable for industrial production.

The invention provides a transaminase mutant and application of the transaminase mutant in preparation of R-3-aminobutanol, and relates to the technical field of biology. The transaminase mutant provided by the invention is obtained by mutating wild type transaminase with an amino acid sequence as shown in SEQ ID NO.1, and the mutations comprise that histidine at the 62nd site is mutated into arginine, serine, threonine or cysteine, and / or glycine at the 136th site is mutated into phenylalanine. Compared with wild transaminase, the transaminase mutant has higher enzymatic activity, can efficiently catalyze 4-hydroxy-2-butanone to generate R-3-aminobutanol, and is further used for preparing dolutegravir.

The present invention relates to a new co-crystal of Gabapentin, Ketoprofen and Lysine, to pharmaceutical compositions and to their use in the prevention, reduction or treatment of pain and / or inflammation.

The invention discloses a benzamide / benzenesulfonamide compound containing an aryl butanone structure as well as a preparation method and application of the benzamide / benzenesulfonamide compound, and belongs to the technical field of medicinal chemistry. The structure of the benzamide compound containing the aryl butanone structure is as follows: R1 is hydrogen, halogen, alkyl or alkoxy; r2 is a tert-butyl group, a tert-amyl group, a tert-octyl group, an adamantyl group or an alpha, alpha-dimethyl benzyl group; r3 is hydrogen, halogen, alkyl, alkoxy, fused ring or aryl; r4 is hydrogen, alkyl or aryl. The structure of the benzenesulfonamide compound containing the aryl butanone structure is as follows: R1 is hydrogen, halogen or alkyl; r2 is tert-butyl, tert-amyl or tert-octyl; and R3 is hydrogen, halogen, alkyl or fused ring. The invention has the following beneficial effects: part of the prepared compounds have strong inhibition effect on MCF-7 and HCT-116, and can be used as drug lead compounds for subsequent preparation and research and development of antitumor drugs.

The invention discloses application of 1-hydroxy-2-butanone in preparation of a medicine for treating acute liver injury, belongs to the technical field of medicines, and particularly relates to application of 1-hydroxy-2-butanone in treatment of acetaminophen-induced liver injury. Experiments prove that 1-hydroxy-2-butanone can remarkably improve the survival rate of mice suffering from liver injury induced by acetaminophen (APAP) and remarkably relieve liver tissue necrosis and neutrophil infiltration, and serum biochemical detection further proves that when 1-hydroxy-2-butanone is adopted for treatment, the liver injury can be obviously relieved by reversing the oxidative stress level caused by APAP, and the survival rate of the mice suffering from liver injury induced by APAP can be obviously reduced. The liver function impairment caused by APAP is obviously reduced.

The present disclosure is directed, in general, to synthesizing optionally substituted 2-dicyanomethylene-3-cyano-4-methyl-5-phenyl-5-perfluoromethyl-2,5-dihydrofuran comprising (i) reacting tributyl(1-ethoxyvinyl)tin with n-butyllithium at a temperature of between -30 °C and 10 °C to produce a first reaction product; (ii) reacting the first reaction product with 2,2,2-trifuoroacetophenone to produce a second reaction product: (iii) quenching the second reaction product with an acid to produce 3-hydroxy-3-phenyl-4,4,4-trifluoro-2-butanone; and (iv) reacting the 3-hydroxy-3-phenyl-4,4,4-trifluoro-2-butanone with malononitrile in the presence of base to produce 2-dicyanomethylene-3-cyano-4-methyl-5-phenyl-5-perfluoromethyl-2,5-dihydrofuran.