Alpha position heteroatom substituted gamma aryl ketobutyric acid derivative, process, pharmaceutical combination and uses thereof

A compound and heterocyclic group technology, applied in the field of butanone acid derivatives, can solve the problems of skeletal muscle and joint damage, no obvious anti-tumor or anti-inflammatory effect, no significant curative effect, etc.
CN1566065AInactive Publication Date: 2005-01-19INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI
7 Cites 12 Cited by

Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI
Publication Date
2005-01-19
Estimated Expiration
Not applicable · inactive patent

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention relates to a gamma methyl ethyl ketone acid derivative represented by general formula (I), and contains gamma-aryl-alpha-amido-beta, its preparing process, pharmaceutical compositions containing them and use as medicament, in particular as medicament for treating osteoarthritis and tumor.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The present invention relates to butyronic acid derivatives, their preparation method, their pharmaceutical composition, and their use as medicine, especially as medicine for treating osteoarthritis and tumor. Background technique

[0002] Matrix metalloproteinases (Matrix Metalloproteinases, MMPs) is a general term for a class of endopeptidases whose active sites contain zinc ions, and exist on the extracellular matrix and membrane surface. It is mainly secreted by fibroblasts, neutrophils, macrophages and tumor cells in the form of inactive zymogen, and activated by corresponding enzymes in the extracellular matrix (Extra Cellular Matrix, ECM). MMPs can hydrolyze different protein substrates, such as: collagen, gelatin, proteoglycan, fibroblast, elastin, etc. It is regulated in three ways in vivo: mediated by cytokines and growth factors; activation of zymogens; participation of endogenous inhibitors (TIMPs, Tissue Inhibitors of Matrix Metalloprotei...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More