Gel for inhibiting acne

A technology for gel and acne, applied in acne skin care products and its preparation, in the field of sodium hyaluronate gel, which can solve the problems of gel physical state influence, instability, etc., to promote wound healing, excellent lubricating effect, improve The effect of moisturizing water holding capacity

Active Publication Date: 2020-05-05
BLOOMAGE BIOTECHNOLOGY CORP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the problem that the physical state of the gel is easily affected by pH and unstable in the prior art, the present invention provides a gel for inhibiting acne with hyaluronic acid as the base, which has good effect, stable physical state, and is not affected by acid and alkali. influences

Method used

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  • Gel for inhibiting acne
  • Gel for inhibiting acne
  • Gel for inhibiting acne

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Example 1 Preparation of Sophora Sophora Extract and Forsythia Extract

[0038] The Sophora flavescens extract is prepared by the following method: take an appropriate amount of Sophora flavescens medicinal material, add 10 times the amount of water to soak for 30 minutes, boil on low heat, keep a slight boil for 30 minutes, filter, add 8 times the amount of water to decoct the filter residue for 30 minutes, keep Slightly boil, filter, combine the twice filtered decoction, concentrate the decoction under reduced pressure to a relative density of 1.15 (at room temperature), and spray dry to obtain Sophora flavescens extract;

[0039] The forsythia extract is prepared by the following method: take an appropriate amount of forsythia, crush it into a coarse powder, add 10 times the amount of water to decoct 3 times, each time for 1.5 hours, filter, combine the filtrate, and concentrate the filtrate under reduced pressure below 60°C To a clear paste with a relative density o...

Embodiment 2

[0040] Example 2 Preparation of Gel for Suppressing Acne

[0041] Weigh each raw material according to the ratio in the table below:

[0042]

[0043] Prepared as follows:

[0044] (1) Take Sophora flavescens extract, forsythia extract, ectoine, vitamin C or azelaic acid and add appropriate amount of purified water respectively, stir evenly to obtain solution A;

[0045] (2) Add sodium hyaluronate into solution A, stir evenly until the solution is clear and transparent, and obtain solution B;

[0046](3) Take glycerin, add ethylparaben to glycerin, stir evenly, and obtain solution C;

[0047] (4) Slowly add solution C to solution B, and stir while adding to make the mixture uniform, and the acne-suppressing gel is obtained.

[0048] Wherein, the pH value of sample 1 is 5.8, the pH value of sample 2 is 5.8, the pH value of sample 3 is 5.8, and the pH value of sample 4 is 5.0.

Embodiment 3

[0080] Embodiment 3 Physicochemical properties, antibacterial effect and therapeutic effect of different gel samples

[0081] 1. Gel properties of different samples

[0082] The sodium hyaluronate gel sample 1 that embodiment 2 makes and the carbomer gel sample 5 that comparative example 1 makes and the sodium carboxymethyl cellulose gel sample 6 that comparative example 2 makes carry out shear viscosity and shear frequency determination to compare the gel properties of the three:

[0083] Under the condition of 25±2°C, the rheometer was used at the shear rate from 0.001 s -1 -1000s -1 Peristaltic scanning was carried out under the following conditions, with the shear rate as the abscissa and the shear viscosity as the ordinate, the shear viscosity trend diagram of the test product was obtained. According to the trend diagram, select the appropriate shear rate in the first Newton zone, and measure the shear viscosity of the test product. The shear viscosity of sample 1 was...

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Abstract

The invention provides a gel for inhibiting acne. The gel comprises the following raw materials: 0.8-1.2% of sodium hyaluronate, 0.2%-0.8% of glycerol, 0.3%-0.8% of Ectoin, 0.005%-.008% of vitamin C,5%-15% of a radix sophorae flavescentis extract, 2%-7% of forsythia suspensa extract, 0.2%-0.5% of ethylparaben, with the balance being purified water, wherein the molecular weight range of the sodiumhyaluronate is 2 * 10<3>kDa to 3 * 10<3>kDa. The sodium hyaluronate gel prepared from the above raw materials has the characteristics of good stability, high safety, good lubricating effect, high comfort, no stickiness and no drug tolerance, and also has the effects of clearing heat, drying dampness, eliminating stagnation, diminishing swelling, resisting inflammation and killing bacteria.

Description

technical field [0001] The invention belongs to the field of cosmetics, and relates to an acne-removing skin care product and a preparation method thereof, in particular to a sodium hyaluronate gel for inhibiting acne. Background technique [0002] Acne is a chronic pilosebaceous gland disease and one of the most common skin diseases in dermatology. The occurrence of acne is mainly closely related to factors such as excessive sebum secretion, pilosebaceous gland duct blockage, bacterial infection and inflammatory response. When acne breaks out, it will cause dilation of capillaries in the skin. After subsided, the blood vessels cannot rebound quickly, and erythema will form on the skin, and even cause pigmentation, resulting in dull skin. Acne can cause the skin to bulge during the onset process, and it is often accompanied by dry and desquamated skin after it subsides. Acne tends to occur in adolescence, and it also occurs in people over 30 years old. Although acne is oft...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/9789A61K8/73A61K8/67A61K8/49A61K8/37A61K8/34A61K8/04A61P17/10A61Q19/00
CPCA61K8/9789A61K8/676A61K8/735A61K8/4953A61K8/37A61K8/345A61K8/042A61Q19/00A61P17/10
Inventor 庞萌萌李超杨盛林田晨颖刘建建郭学平
Owner BLOOMAGE BIOTECHNOLOGY CORP LTD
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