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Veterinary medicine for preventing and treating chicken bursal disease and its preparation method and application

A veterinary drug, chicken method technology, applied in the field of medicine, can solve the problems of low cellulose digestibility, low drug absorption and utilization rate, short passage time, etc., so as to reduce the risk of bursal disease, shorten the recovery time, and reduce degradation. Effect

Active Publication Date: 2021-11-26
太原市恩禾动物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0017] However, traditional Chinese veterinary medicine powder is often crushed (low-speed pulverized) in a conventional way in the prevention and treatment of poultry diseases. Because chickens have a short intestine, the passage time of drugs in the digestive tract is very short compared with livestock, and the digestion of cellulose Low capacity, the digestive enzymes in the digestive juice can only extract a small part of the active ingredients in the drug under the influence of the drug cell wall, the absorption and utilization rate of the drug is low, the dosage per unit weight is large, and the effect is slow, resulting in a lot of waste

Method used

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  • Veterinary medicine for preventing and treating chicken bursal disease and its preparation method and application
  • Veterinary medicine for preventing and treating chicken bursal disease and its preparation method and application
  • Veterinary medicine for preventing and treating chicken bursal disease and its preparation method and application

Examples

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Effect test

Embodiment 1

[0052] Embodiment 1: A kind of veterinary medicine for preventing and treating chicken bursal disease, raw materials are weighed according to the following proportions: 200 parts of Radix Astragali, 200 parts of Radix Paeoniae Alba, 150 parts of Ophiopogon japonicus, 100 parts of Epimedium, 100 parts of Ligustrum lucidum 80 parts of isatidis, 50 parts of raw land, 40 parts of red peony root, 30 parts of paeonol, 30 parts of dandelion, 30 parts of diding, enzymatic hydrolysis of the combined medicine to obtain the extract, freeze-dried and then added Aronia black fruit to freeze-dry 60 parts of fruit powder are prepared into compound medicine.

[0053] Preparation method: Ultrafine pulverization respectively, adding 1.5% combined enzyme of traditional Chinese medicine quality, wherein the mass ratio of cellulase: pectinase is 2:1, enzymatic hydrolysis at pH 5.0, 50°C for 50 min, heating for 90 ℃, 15 min to inactivate the enzyme, then ultrasonic extraction at 60 °C, 40KHz for 40...

Embodiment 2

[0055] Embodiment 2: A kind of veterinary medicine for preventing and treating chicken bursal disease, raw materials are weighed according to the following proportions: 150 parts of Radix Astragali, 150 parts of Radix Paeoniae Alba, 100 parts of Ophiopogon japonicus, 80 parts of Epimedium, 100 parts of Ligustrum lucidum 75 parts of Radix Isatidis, 50 parts of freeze-dried fruit powder of Aronia nigra, extracted and made into oral liquid.

[0056] Preparation method: Superfinely pulverize the above traditional Chinese medicines respectively, add combined enzymes with a mass of 2.0% of raw materials, wherein the mass ratio of cellulase: pectinase is 2:1, enzymatically hydrolyze at pH 5.0, 50°C for 50 min, heat Inactivate the enzyme at 90°C for 15 min, and then conduct ultrasonic extraction at 60°C and 40 KHz for 40 min, separate the solid and liquid to obtain the supernatant, then add 10 times the mass fraction of water to the solid for ultrasonic extraction, and repeat twice, ea...

Embodiment 3

[0058] Example 3: A kind of veterinary medicine for preventing and treating chicken bursal disease, raw materials are weighed according to the following ratio: 100 parts of Radix Astragali, 100 parts of Radix Paeoniae Alba, 75 parts of Ophiopogon japonicus, 100 parts of Epimedium, 150 parts of Ligustrum lucidum 150 parts of isatidis, 40 parts of raw land, 40 parts of red peony root, 30 parts of paeonol, 30 parts of dandelion, 20 parts of diding, 80 parts of freeze-dried fruit powder of Sorbus nigra, prepared into powder after extraction.

[0059]Preparation method: Superfinely pulverize the above eleven traditional Chinese medicines respectively, add 1.0% of the mass of the traditional Chinese medicine combined enzyme, wherein the mass ratio of cellulase: pectinase is 2:1, enzymatically hydrolyze at pH 5.0, 50°C 50 min, heat at 90°C, inactivate the enzyme for 15 min, then ultrasonically extract at 60°C and 40 KHz for 40 min, separate the solid and liquid to get the supernatant,...

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Abstract

The invention discloses a veterinary medicine for preventing and treating chicken bursal disease and its preparation method and application. The veterinary medicine comprises the following components in parts by mass: 100-300 parts of astragalus, 100-300 parts of white peony, wheat 50-250 parts of winter, 50-200 parts of Epimedium, 50-200 parts of Ligustrum lucidum, 50-150 parts of Radix Isatidis, and 30-80 parts of freeze-dried fruit powder of Sorbus nigra. The preparation method of the veterinary drug is as follows: (1) weighing the traditional Chinese medicines except the freeze-dried fruit powder of Aronia nigricarpa according to the mass fraction, pulverizing them, adding enzymes for enzymolysis to obtain the enzymolysis solution; (2) ultrasonically extracting the enzymolysis solution , solid-liquid separation, adding water to the solid, ultrasonic extraction, filtering, to obtain the filtrate; centrifuging the filtrate while it is hot, to obtain the supernatant; (3) heating the supernatant, lyophilizing after vacuum concentration, pulverizing, and adding to it Add Sorbus nigra, mix well, and serve. Compared with the prior art, the present invention can effectively improve the activity of veterinary medicine by adding Aronia nigra at the end.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a veterinary medicine for preventing and treating chicken bursal disease, a preparation method and application thereof. Background technique [0002] The demand of the market has enabled the rapid development of animal husbandry. In order to promote the growth of animals, shorten the growth cycle of animals, and improve the economic benefits and production efficiency of farming, more and more feed additives have been developed and widely used in animal husbandry. German researchers added aspartic acid to sheep feed, which is a synthetic non-protein nitrogen substance, and found that the nitrogen content in sheep blood increased significantly. Some antibiotics are used as additives in animal feed to prevent livestock and poultry diseases to a certain extent, but long-term use leads to serious consequences, and the disadvantages are becoming more and more obvious. Since chemic...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8968A61P31/14A61P37/04
CPCA61K36/195A61K36/288A61K36/296A61K36/315A61K36/481A61K36/638A61K36/65A61K36/71A61K36/73A61K36/804A61K36/86A61K36/8968A61K2236/19A61K2236/331A61P31/14A61P37/04A61K2300/00
Inventor 李睿阮文辉叶松华刘冠群吴哲冯夏珍张娇
Owner 太原市恩禾动物药业有限公司
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