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Hematoxylin-eosin staining pathological image hierarchical segmentation method and terminal

A pathological image, hierarchical segmentation technology, applied in the field of image processing, can solve the problems of poor generalization ability, difference, difficult to establish a stable shape model, etc., to achieve the effect of improving speed and accuracy, reducing difficulty, and facilitating segmentation processing.

Active Publication Date: 2020-05-29
FUJIAN NORMAL UNIV
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Problems solved by technology

[0003] Because the staining quality of traditional pathological image segmentation methods is easily affected by external factors, there will be large differences in staining results, and there is no obvious boundary between the nucleus, cytoplasm, and extracellular space after staining, and the diversity of cell nucleus morphology will As a result, it is difficult to establish a stable shape model in the process of nucleus detection and segmentation, and the generalization ability is poor

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  • Hematoxylin-eosin staining pathological image hierarchical segmentation method and terminal
  • Hematoxylin-eosin staining pathological image hierarchical segmentation method and terminal
  • Hematoxylin-eosin staining pathological image hierarchical segmentation method and terminal

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Embodiment 1

[0075] Please refer to Figure 1-Figure 12 , Embodiment 1 of the present invention is:

[0076] A method for hierarchical segmentation of hematoxylin-eosin stained pathological images, specifically, comprising the following steps:

[0077] S1. Perform preprocessing and feature selection on the original hematoxylin-eosin stained pathological image in sequence to obtain a feature set;

[0078] like Figure 4 As shown, specifically, step S1 includes:

[0079] The original hematoxylin-eosin stained pathological images were preprocessed by median filtering and Gaussian filtering successively;

[0080] Preferably, a median filter and a Gaussian filter with a window size of 5×5 and a step size of 1 are used;

[0081] Decompose hematoxylin-eosin stained RGB pathological images into three monochrome images of red, green and blue and convert them into grayscale images respectively as alternative features;

[0082] The hematoxylin-eosin stained image segmentation model based on hier...

Embodiment 2

[0115] Please refer to Figure 1-Figure 12 , the second embodiment of the present invention is:

[0116] A terminal for hierarchical segmentation of hematoxylin-eosin stained pathological images, the terminal includes a memory 1, a processor 2, and a computer program stored in the memory 1 and operable on the processor 2, the processor 2. The various steps in Embodiment 1 are realized when the computer program is executed.

[0117] In summary, the present invention provides a method and terminal for hierarchical segmentation of hematoxylin-eosin stained pathological images, through the preprocessing and feature selection of the original hematoxylin-eosin stained pathological images, to obtain color The two-dimensional feature set of intensity information is convenient for subsequent segmentation; further, K-means clustering and naive Bayesian classification are performed on the image, and the image is segmented step by step to obtain a complete nucleus area, narrow the segmen...

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Abstract

The invention relates to a hematoxylin-eosin staining pathological image hierarchical segmentation method. The method comprises steps of obtaining a pathological image according to color intensity information of pixels in the pathological image; carrying out preprocessing and feature selection on the original image; gradually carrying out segmentation of three levels of K-means clustering, naive Bayesian classification and watershed segmentation, obtaining the precise boundary between the cell nucleuses, wherein accurate boundary segmentation of cell nucleuses in pathological images is a difficult point in pathological image segmentation, and the method significantly improves the segmentation precision of cell nucleus boundaries of hematoxylin-eosin staining pathological images while ensuring correct segmentation of regions, thereby improving the accuracy of cell nucleus counting results and morphological feature measurement.

Description

technical field [0001] The invention relates to the field of image processing, in particular to a method and terminal for hierarchical segmentation of hematoxylin-eosin stained pathological images. Background technique [0002] Hematoxylin-eosin (HE) staining is one of the most commonly used technologies in paraffin section technology, and the application of hematoxylin-eosin staining in pathological image segmentation technology is the most practical technology in medical image processing technology one. In the field of medical research, digital pathological segmentation methods have been widely promoted and applied. However, due to the increasing number of hematoxylin-eosin-stained pathological images in the database, the automatic segmentation processing speed of images has been increasingly raised. high demands. [0003] Because the staining quality of traditional pathological image segmentation methods is easily affected by external factors, there will be large differ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G06T7/11G06T7/155G06T7/187G06T7/90G06K9/62
CPCG06T7/11G06T7/155G06T7/187G06T7/90G06T2207/10024G06T2207/20152G06T2207/30024G06F18/23213G06F18/24155
Inventor 时鹏吴崇数钟婧王开军
Owner FUJIAN NORMAL UNIV
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