Lung cancer auxiliary diagnosis method based on ERCC5 gene and environmental polycyclic aromatic hydrocarbon exposure interaction

Abstract

The invention relates to a lung cancer auxiliary diagnosis method based on ERCC5 gene and environmental polycyclic aromatic hydrocarbon exposure interaction. Specifically, according to the rs17655 gene carrying condition of a to-be-diagnosed object, different genotypes, genders, ages, smoking or not of SNP, the number of years of smoking packets and the concentration of urine 3-hydroxyphenanthrenein urine, the disease risk of lung cancer is jointly judged. The invention provides a technical method for screening lung cancer high-risk groups on the basis of considering the combined action of cyclic genetic factors and environmental factors. According to the method, rs17655 variation of normal people is detected, meanwhile, the concentration of 3-hydroxyphenanthrene in urine is measured, andthe two measurement results are combined, so that high-risk people with lung cancer are identified, and lung cancer diagnosis is assisted. The method is simple and feasible, the result is accurate and credible, help is provided for evaluating the disease risk of lung cancer, and lung cancer screening and early intervention can be further carried out on high-risk groups clinically.

Description

technical field [0001] The invention relates to the field of lung cancer diagnosis methods, in particular to an auxiliary diagnosis method for lung cancer based on the interaction between ERCC5 gene and environmental polycyclic aromatic hydrocarbon exposure. Background technique [0002] Lung cancer is the most common cancer in China and the leading cause of cancer-related death in China. The incidence of lung cancer in China is growing rapidly. It is estimated that by 2025, more than 1 million people will die of lung cancer. Of the roughly 19,702 patients with stage I lung cancer, the 5-year survival rate for those who underwent surgery was 54%, compared with 6% for untreated patients, and the standardized death rate is expected to continue to rise. Many hospitals in China still use chest X-rays, sputum examination, and bronchoscopy to screen and diagnose lung cancer, resulting in late diagnosis and their limited role in improving survival. According to foreign reports, lo...

AI Technical Summary

Problems solved by technology

Many hospitals in China still use chest X-rays, sputum examination and bronchoscopy to screen and diagnose lung cancer, resulting in late diagnosis and their limited role in improving survival rates

According to foreign reports, low-dose computed tomography (LDCT) screening can reduce lung cancer mortality by 20%, but considering the large number of eligible screening objects, the potential cost is very expensive. In addition, CT screening Research studies are also associated with high rates of false positive results

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