A kind of ion exchange fiber chloroquine suspension and preparation method thereof
An ion-exchange fiber and cation-exchange technology, applied in the field of medicine, can solve problems such as large fluctuations in blood drug concentration
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Embodiment 1
[0041] Embodiment 1 ion exchange fiber chloroquine suspension preparation
[0042] Ion exchange fiber chloroquine suspension preparation method is as follows:
[0043] (1) Take the cation exchange fiber, soak it repeatedly in water, ethanol, 1.0mol / L NaOH solution and 1.0mol / L HCl solution in sequence respectively, so that the fiber is converted into hydrogen form, filter it with suction, rinse it with deionized water until neutral, first Use a 60-mesh filter to carry out primary screening, and then use an 80-mesh filter to carry out a second sieve for the ionic fiber that passed through the sieve, and take the ionic fiber that did not pass through the second sieve, dry it for later use, and obtain raw material 1;
[0044] (2) Weigh 50g of raw material 1, 60g of chloroquine phosphate, add 500ml of deionized water, and stir at a constant temperature of 45°C for 20min to obtain solution 1;
[0045] (3) Weigh 10g of xylitol and 0.05g of EDTA, and add them to 300ml of deionized w...
Embodiment 2
[0048] Embodiment 2 ion exchange fiber chloroquine suspension preparation
[0049]Ion exchange fiber chloroquine suspension preparation method is as follows:
[0050] (1) Take the cation exchange fiber, soak it repeatedly in water, ethanol, 1.0mol / L NaOH solution and 1.0mol / L HCl solution in sequence respectively, so that the fiber is converted into hydrogen form, filter it with suction, rinse it with deionized water until neutral, first Use 80 mesh filter screens to carry out primary screening, then use 100 mesh filter screens to carry out secondary sieving for the ionic fibers that pass through the sieve screens, take the ionic fibers that do not pass through the 2nd sieve filter screens, dry for standby, and obtain raw material 1;
[0051] (2) Weigh 50g of raw material 1, 60g of chloroquine phosphate, add 500ml of deionized water, and stir at a constant temperature of 45°C for 20min to obtain solution 1;
[0052] (3) Weigh 10g of xylitol and 0.05g of EDTA, and add them to ...
Embodiment 3
[0055] Embodiment 3 ion exchange fiber chloroquine suspension preparation
[0056] Ion exchange fiber chloroquine suspension preparation method is as follows:
[0057] (1) Take the cation exchange fiber, soak it repeatedly in water, ethanol, 1.0mol / L NaOH solution and 1.0mol / L HCl solution in sequence respectively, so that the fiber is converted into hydrogen form, filter it with suction, rinse it with deionized water until neutral, first Use a 100-mesh filter to carry out primary screening, then use a 120-mesh filter to carry out a second sieve for the ionic fiber that passed through the sieve, take the ionic fiber that did not pass through the second sieve, dry it for later use, and obtain raw material 1;
[0058] (2) Weigh 50g of raw material 1, 60g of chloroquine phosphate, add 500ml of deionized water, and stir at a constant temperature of 45°C for 20min to obtain solution 1;
[0059] (3) Weigh 10 g of xylitol and 0.05 g of EDTA and add them into 300 ml of deionized wate...
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