Standard comparison card for assisting in interpreting KI67 proliferation index

A KI67 and comparison card technology, applied in image enhancement, image data processing, material inspection products, etc., can solve the problems of unguaranteed reliability of results, lack of KI67 interpretation, etc., and achieve low cost, high accuracy, and easy to use convenient effect
CN111413504AActive Publication Date: 2020-07-14FOURTH HOSPITAL OF HEBEI MEDICAL UNIV
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Patent Information

Authority / Receiving Office
CN Β· China
Current Assignee / Owner
FOURTH HOSPITAL OF HEBEI MEDICAL UNIV
Publication Date
2020-07-14

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Abstract

The invention relates to the field of immunohistochemical detection, and particularly discloses a preparation method of a standard comparison card for assisting in interpretation of a KI67 proliferation index. The method comprises the following steps: 1) scanning tumor tissue sections chemically stained by KI67 immunohistochemistry by a full-automatic digital section scanning system to obtain image data; 2) selecting a hot spot area in the image data, and interpreting the proportion of the KI67 positive cells in the hot spot area in tumor cells in the hot spot area by using a computer to obtain a KI67 proliferation index; 3) capturing more than one picture of the hot spot region with the known KI67 proliferation index. The standard comparison card provided by the invention is advantageousin that the accuracy is good, the influence by the qualification age limit of doctors is not easy, and the doctors can be assisted to stably judge the KI67 proliferation indexes.
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Description

technical field

[0001] The invention relates to the field of immunohistochemical detection. Background technique

[0002] KI67 is a non-histone nuclear cortex protein that is expressed in the nucleus in the G1, S, G2 and M phases of the cell cycle, but not in the G0 phase (the quiescent state of the cell). Therefore, the proportion of cells expressing KI67 in tumor cells (also called "KI67 proliferation index") can reflect the proportion of dividing cells in tumor cells, and is often used to judge the malignancy of tumors. The higher the KI67 proliferation index, usually The higher the degree of malignancy.

[0003] The KI67 proliferation index has emerged as a predictive and prognostic factor for breast cancer (BC). According to St. Gallen's guidelines, high proliferation KI67 is one of the characteristics of an increased risk of recurrence in estrogen receptor (ER)-positive HER2-negative BC, indirectly supporting the value of adding chemotherapy to endocrine therapy in t...

Claims

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