Standard comparison card for assisting in interpreting KI67 proliferation index
A KI67 and comparison card technology, applied in image enhancement, image data processing, material inspection products, etc., can solve the problems of unguaranteed reliability of results, lack of KI67 interpretation, etc., and achieve low cost, high accuracy, and easy to use convenient effect
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Embodiment 1
[0026] Embodiment 1 The making and using method of the standard comparison card of the present invention
[0027] Use the PRECICE 600 series automatic digital slide scanning system to scan breast cancer tumor sections stained with KI67 immunohistochemistry and convert them into whole slide image data. The area with the highest proportion of KI67 positive cells was selected as the "hot spot" area, and the proportion of KI67 positive cells in the hot spot area to the tumor cells in the hot spot area was judged by computer, which was the KI67 proliferation index, and the KI67 proliferation index was selected as 5%, 10%, and 15% respectively. %, 20%, 30%, 40%, 50%, 60%, 70%, 80% of the area, intercept the area of the picture, and print it in color.
[0028] When in use, it is only necessary to compare the KI67 immunohistochemical staining section of the breast cancer to be tested with each standard comparison card to find the closest standard comparison card, and the KI67 prolif...
Embodiment 2
[0029] Embodiment 2 The making and using method of the standard comparison card of the present invention
[0030] Use the PRECICE 600 series automatic digital slide scanning system to scan breast cancer tumor sections stained with KI67 immunohistochemistry and convert them into whole slide image data. The area with the highest proportion of KI67 positive cells was selected as the "hot spot" area, and the proportion of KI67 positive cells in the hot spot area to the tumor cells in the hot spot area was judged by computer, which was the KI67 proliferation index, and the KI67 proliferation index was selected as 15%, 20%, and 30%, respectively. %, 50%, 80% of the area, intercept the area of the picture, print in color, and get 10 different standard cards.
[0031] When in use, it is only necessary to compare the K167 immunohistochemical staining section of the breast cancer to be tested with each standard comparison card to find the closest standard comparison card, and the KI67...
experiment example 1
[0034] Experimental Example 1 The effect verification of the standard comparison card of the present invention
[0035] The purpose of this experimental example is to compare the influence of the interpreter using the conventional interpretation method (method 1), the method using the conventional standard comparison card (method 2) and the method of the standard comparison card of the present invention (method 3).
[0036] The method 1 is: in the daily work of the pathologist, without any auxiliary tools, select a hotspot area in the KI67 immunohistochemically stained glass slide under the microscope, and manually interpret the proportion of KI67 positive cells, which is the KI67 proliferation index of breast cancer;
[0037] The method 2 is based on the embodiment 1, and the computer interpretation of the KI67 proliferation index is changed to manual counting, specifically:
[0038] Use the PRECICE 600 series fully automatic digital slide scanning system to scan the KI67 imm...
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