96 results about "Digital slide" patented technology

A networkable power controller includes a mode selector for selectively conducting of a plurality of input signals to an output of the networkable power controller, where the input signals and the output signals satisfy the same signaling protocol. The networkable power controller may be networked with other networkable power controllers, lighting ballasts and other building automation control devices, and user-controlled voltage selectors to provide a lighting control network. A power controller may include a mode selector that may be used in combination with other control devices or components, including a rotary dimmer control, a digital slide dimmer control, a demand load shedder component, a photometer component, and a communications interface. The communications interface allows digital control of the networkable power controller.

A whole slide fluorescence digital pathology system is provided that uses a monochrome TDI line scan camera, which is particularly useful in fluorescence scanning where the signal is typically much weaker than in brightfield microscopy. The system uses oblique brightfield illumination for fast and accurate tissue finding and employs a unique double sweep focus scoring and objective lens height averaging technique to identify focus points and create a focus map that can be followed during subsequent scanning to provide autofocusing capability. The system also scans and analyzes image data to determine the optimal line rate for the TDI line scan camera to use during subsequent scanning of the digital slide image and it also creates a light profile to compensate for loss of illumination light due to roll off.

An array of microscopes and a method of imaging an object with the array of microscopes. The array includes a plurality of optical elements being individually disposed with respect to a corresponding image plane and configured to image respective sections of an object, and includes a plurality of image sensors corresponding to respective optical elements and configured to capture corresponding representations of the respective sections of the object. The method includes imaging respective sections of an object with a plurality of optical elements and capturing corresponding representations of sections of the object from a plurality of image sensors.

Systems and methods for improving quality assurance in pathology using automated quality assessment and digital image enhancements on digital slides prior to analysis by the pathologist are provided. A digital pathology system (slide scanning instrument and software) creates, assesses and improves the quality of a digital slide. The improved digital slide image has a higher image quality that results in increased efficiency and accuracy in the analysis and diagnosis of such digital slides when they are reviewed on a monitor by a pathologist. These improved digital slides yield a more objective diagnosis than reading the corresponding glass slide under a microscope.

A networkable power controller includes a mode selector for selectively conducting one of a plurality of input signals to an output of the networkable power controller, where the input signals and the output signals satisfy the same signaling protocol. The networkable power controller may be networked with other networkable power controllers, lighting ballasts and other building automation control devices, and user-controlled voltage selectors to provide a lighting control network. A power controller may include a mode selector that may be used in combination with other control devices or components, including a rotary dimmer control, a digital slide dimmer control, a demand load shedder component, a photometer component, and a communications interface. The communications interface allows digital control of the networkable power controller.

A digital slide analysis system comprises an algorithm server that maintains or has access to a plurality of image processing and analysis routines. The algorithm server additionally has access to a plurality of digital slide images. The algorithm server executes a selected routine on an identified digital slide and provides the resulting data. Prior to the application of selected routine, the system employs a digital pre-processing module to create a metadata mask that reduces undesirable image data such that the image data processed by the selected routine has an improved signal to noise ratio. The pre-processing module uses a classifier that may be implemented as a pattern recognition module, for example. Undesirable image data is therefore excluded from the image data that is processed by the digital pathology image processing and analysis routine, which significantly improves the digital pathology image analysis.

The present invention relates to an image-based computer-aided prognosis (CAP) system and method that seeks to replicate the prognostic power of molecular assays in histopathology and pathological processes, including but not limited to cancer. Using only a tissue slide samples, a mechanism for digital slide scanning, and a computer, the present invention relates to an image-based CAP system and method which aims to overcome many of the drawbacks associated with prognostic molecular assays (e.g. Oncotype DX) including the high cost associated with the assay, limited laboratory facilities with specialized equipment, and length of time between biopsy and prognostic prediction.

A system that determines the quality of a digital microscope slide by analyzing digital slide images based on complexity and spatial frequencies. An example embodiment detailed in the application may provide visual feedback on the whole slide quality by overlaying the image with a color coded “heat map” of local area quality. A user provided with the overlap image may obtain both an absolute quality measurement for the whole image and quickly identity the quality variability within the slide.

A novel and useful method and system of optimized image compression of digital pathology slide images. The optimized image compression mechanism exploits the special color properties of the stained tissue represented by the digital pathology slides and provides an image compression algorithm having improved rate-distortion performance. Optimized color transforms are pre-computed using training sets of pathology slide image scan data for each stain type. The optimized color transforms are used to compress input slide image scans resulting in more efficient image streaming enabling users to review extremely large digital slide scans from any connected location, such as in a hospital, satellite center, home or on a mobile telephone.

The invention relates to a morphology teaching system based on a panoramic intelligent scanning digital slide technology, and the system adopts a B / S architecture comprising a client, a network, an application server, a database, a panoramic scanning digital slide system and a streaming media production system, wherein, the client is connected with the application server through the network; the client is provided with client tools including an IE browser and a Flash player; the database comprises a spectral database and a streaming media database; the application server responds to a request of the client for querying the database and returns a queried spectral result to the client; and the application server realizes the playing of a streaming media courseware. The panoramic scanning digital slide system scans a tissue slicer, leads the scanned slicer to generate a micro-morphologic spectrum with the conventional picture format and stores in the spectral database; and the streaming media production system generates the streaming media teaching courseware.

The invention discloses a digital slide real-time scanning automatic focus system and method. The system comprises an optical microscope device, a dispersion prism, a focus controller, a displacement controller, a first imaging device and a second imaging device, wherein the focus controller adjusts the first imaging device and the second imaging device so that the first imaging device and the second imaging device can have a common view field. The dispersion prism splits a light path from the common view field into a first light path and a second light path. The first imaging device receives the first light path and forms a first image, and the second imaging device receives the second light path and forms a second image. The displacement controller estimates the position of a focus face of the next view field according to focus factor analyzing results of the two images of the current view field, and controls an object stage or an object lens to move to the next view field, so that the object stage or the object lens moves to the focus face of the next view field. According to the scheme, the digital slide real-time scanning automatic focus system is well compatible with a traditional optical microscope device, and repeated development is needless. Besides, the digital slide real-time scanning automatic focus system and method can obtain the best focus face quickly, and the obtained focus face is high in precision.

Systems and methods are provided to facilitate consultations between a referral source (e.g., labs, pathologists and patients) and a consultant (e.g., pathologist, radiologist, or other digital image analyst). Links between the various referral sources and consultants are established through a scanning center via a data communication network such as the Internet. The referral source sends a slide to the scanning center where the corresponding digital slide is posted for review and analysis by the consultant. Upon completion of the analysis and report, a digital slide conference is conducted through the scanning center that provides a venue for direct communication regarding the consultation. The scanning center may also facilitate payment from the referral source to the consultant.

The invention discloses a mixed control circuit of a DVS system switch DC-DC converter and a control method of the mixed control circuit of the DVS system switch DC-DC converter. Orderly switching between two control modes is achieved through a mixed digital algorithm based on traditional linear digital PID and nonlinear digital sliding-mode control. In the steady state, a slow loop of a digital PID compensator is selected through the mixed control algorithm to work, and small ripple waves of the output voltage and fast responses to small jumping are achieved. When feedback signals of a DVS algorithm module jump, the loop is compensated by the PID through the mixed control algorithm to stop working, a digital sliding-mode control fast loop is selected, and the DC-DC converter fast gets into the steady state. By means of the mixed control circuit and the control method, the mixed digital control obviously has the high dynamic response speed, and the large the voltage jump amplitude is, the remarkable the advantages are compared with traditional digital PID control. In this way, the mixed digital control DC-DC converter is suitable for DVS systems.

The invention discloses a digital slide real time scanning automatic focusing system and a method thereof. The focusing system comprises an optical microscopic device, an optical spectral device, a focusing controller, a displacement controller, a first auxiliary imaging device and a second auxiliary imaging device, wherein a main imaging device, the first auxiliary imaging device and the second auxiliary imaging device are adjusted by the focusing controller to provide the main imaging device, the first auxiliary imaging device and the second auxiliary imaging device a common field of view, the spectral device is used for dividing a light path from the common field of view into a main light path, a first auxiliary light path and a second auxiliary light path, the focusing controller performs comparative analysis according to focusing factors of a first image, a second image and a main image, the displacement controller estimates the position of a focal plane of next field of view according to the analysis results of the focus controller for three images in the present field of view, and simultaneously the displacement controller controls an object holding stage or an object lens to move to the next field of view. By means of the scheme, compatibility with traditional optical microscopic devices is good, repeated development is not required, fast acquisition of an optimum focal plane is achieved, and accuracy of the acquired focal plane is high.

Systems and methods that acquire digital slides and other large images and store these images into commercially available PACS systems using DICOM-standard messaging are provided. A digital slide or other large two-dimensional image is acquired and each separate resolution level of the digital slide or large image is divided into a series of regions that are each identified as a DICOM image. All of the regions at the same resolution in the digital slide or other large image are collectively identified as a DICOM series. A plurality of DICOM series, representing multiple resolution levels in a digital slide are collectively identified and stored as a DICOM study.

An improved diagnostic resolution of digital slide images is obtained by scanning a first digital slide image at diagnostic resolution that is then deconvolved into separate images with one stain per image. The single stain images are then enhanced with image adjustments and / or processed with image analysis algorithms. The resulting single image data sets from the image analysis algorithms can then be stored. Additionally, the resulting enhanced single images can be recombined into a second digital slide image at diagnostic resolution that is also enhanced.

A portion of imagery data is obtained from a digital slide and a protocol of image analysis / diagnostic tasks is performed on the portion of imagery data by a pathologist or an image analysis module. The result of each task (e.g., success or no success) is recorded and a score is determined for the portion of the imagery data. Multiple portions of imagery data from the digital slide are analyzed and scored and the various scores from the multiple portions of imagery data are calculated to determine an overall score for the digital slide. Regions of the digital slide can be scored separately. Multiple rounds of scoring (by different pathologists and / or different image analysis algorithms) may be employed to increase the accuracy of the score for a digital slide or region thereof.

The invention relates to an automatic digital slide focusing device and method based on a microscope. The automatic focusing device comprises the trinocular microscope and a computer, and the trinocular microscope is provided with an automatic objective table, a scanning ocular lens and a focusing turn button, wherein the automatic objective table can freely move along the axis-Z direction, the scanning ocular lens is provided with a digital camera that is connected with of the computer, and the focusing turn button plays the role of focusing. Clear visual images are obtained in the focusing method, namely an improved over-peaked step-variable hill-climbing focusing search method. The focusing device uses the high-precision automatic objective table, instruction is emitted by the computer, the automatic objective table is controlled to move along the axis-Z direction, the improved over-peaked step-variable hill-climbing focusing search method is used, the high-speed digital camera cooperates with the high-precision automatic objective table, the scanning time of the digital slide is reduced, influence of mechanical error on the focusing effect is reduced, the problem that a traditional step-fixed focusing method leads to oscillation is overcome, and the optimal focal plane can be rapidly and accurately determined.

A slip pulse signal generator of digital type is prepared as using pulse frequency generating circuit to provide clock reference for whole system, using MCU control unit to set all parameters for whole system, using EPGA control unit to control step amplitude generating circuit based on reference of said clock, using internal time sequence module of FPGA control unit to generate control signal for controlling pulse generating circuit to generate pulse signal and realizing design of maximum pulse amplitude control circuit by FPGA control unit in order to achieve purpose of controlling slip signal maximum amplitude.

The invention provides a scanning focus number reducing method of a digital slide scanner. The method comprises the following steps: placing a slide on a scanning platform; scanning the slide to obtain a slide preview of the slide; adjusting the scanning area to be the entire slide; identifying foci; focusing to obtain focal lengths of foci; calculating focal planes according to the focal lengths. The mounting precision of a scanner slide mounting platform and an optical system can be effectively improved, so that a possibility is provided for clearly scanning ultra-large slides (the pixel value of a digital image can reach 100000 x 100000) with few foci. By dividing the parfocal area of the same color, the focus number is further reduced. According to the method provided by the invention, the scanning time can be entirely reduced by 20%.

The invention relates to a digital slide average low-pass filter and a filtering method thereof. The filter comprises a digital filter. The digital filter comprises an A / D converting unit, a first calculation unit, a second calculation unit, a first storage unit and a second storage unit. The A / D converting unit converses a sampling analog signal into a digital signal and send the digital signal to the first calculation unit. The first storage unit stores data cumulative sum output by the first calculation unit. The second storage unit stores a digital filter output value output by the first calculation unit. The first calculation unit reads the data of the first storage unit and the second storage unit and calculates the data cumulative value of the current cycle. The second calculation unit receives the data sent by the first calculation unit and updates and stores the digital filter output value to the second storage unit. According to the invention, a traditional filtering method heavily relying on the memory space of a chip is optimized to the filtering method simply needing two storage units, so that the relying degree of the method on system resources is greatly reduced.

The invention discloses a digital slide storage system. The digital slide storage system comprises a metadata storage module used for storing metadata, and providing writing and reading interfaces of the metadata; an image storage module used for storing slide image data; a slide reconstruction module connected with the image storage module and used for cutting image layers under various magnifications into a plurality of small slide images in a specific patch size; a transmission module connected with the image storage module and the metadata storage module and used for reading slide metadata and image data of different manufacturers, and transmitting the slide metadata and image data to corresponding storage modules; and a browsing module connected with the image storage module and the metadata storage module and used for acquiring and displaying the slide images. The invention further comprises a digital slide browsing method based on the digital slide storage system. The digital slide storage system and the digital slide browsing method provided by the invention can efficiently store digital slides, and can realize instant browsing of the digital slides.