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A traditional Chinese medicine composition for treating lupus nephritis in maintenance stage

A technology of lupus nephritis and composition, which is applied in the field of traditional Chinese medicine composition for the treatment of lupus nephritis in the maintenance stage, can solve the problems of immunosuppressant harm, recurrence prevention effect and complications need to be improved, and achieve good therapeutic effect, low recurrence rate, rapid The effect of steady decline

Active Publication Date: 2021-11-05
AFFILIATED HOSPITAL OF WEIFANG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the above two immunosuppressants can reduce the risk of recurrence to a certain extent, due to the harmfulness of the immunosuppressants themselves to the human body, the effect of preventing recurrence and reducing complications still needs to be improved

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] A traditional Chinese medicine composition for treating maintaining a kerogacy, according to mass, the raw materials include the following components:

[0042] Bupleurum, 12 pieces of 苓, 10 菟 子, 11 gousse, 9 mulberry parasitic, 8 gold spleen share.

[0043] The preparation method is as follows:

[0044] (1) After pulverizing the raw material to 80, at room temperature, the feedstock is placed in water in water for 25 minutes according to the amount of the liquid ratio of 1: 13 g / L;

[0045] (2) After the soaking is completed, the soaking solution containing the raw material is cooked, first heating to boiling, then heating 45min, filtration, removal of the dispersion of the drug, to obtain a Chinese medicine composition for treating the maintenance stage lupine nephritis.

Embodiment 2

[0047] A traditional Chinese medicine composition for treating maintaining a kerogacy, according to mass, the raw materials include the following components:

[0048] Bupleurum, 9 pieces of 苓, 13 菟 子, 9 licorice, 9 mulberry parasitic, 16 gold spots, 12 white flowers, 12 servants, 11 cases of Xianling, 8 share.

[0049] The preparation method is as follows:

[0050] (1) The above-mentioned raw material is pulverized to 50, and the raw material is placed in water in water for 15 min at room temperature.

[0051] (2) After the soaking is completed, the soaking solution containing the raw material is cooked, first uses the fire to boil, and then heating 40min, filtrate, remove the slag, and to obtain a Chinese medicine composition for treating the maintenance stage lupus nephritis.

Embodiment 3

[0053]A traditional Chinese medicine composition for treating maintaining a kerogacy, according to mass, the raw materials include the following components:

[0054] Bupleurum 10 parts, 14 parts of Poria, dodder 8 parts, 11 parts of licorice, mistletoe 8 parts, 15 parts laevigata, 7 parts diffusa, Eclipta 9 parts, 14 parts of Epimedium, dogwood 5 share.

[0055] The preparation method is as follows:

[0056] (1) The above materials were pulverized to 100 mesh, at room temperature, according to the solid-liquid ratio 1: 15g / L, the raw material into water soak for 30 min;

[0057] (2) After completion of dipping, soaking solution containing the raw material is boiling, high heat using first heated to boiling and simmer heating using 50min, filtered to remove the dregs, to obtain the herbal composition for treating a maintenance phase of lupus nephritis.

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Abstract

The invention discloses a traditional Chinese medicine composition for treating lupus nephritis in maintenance stage, belonging to the technical field of traditional Chinese medicines. The raw materials of the traditional Chinese medicine composition of the present invention include the following components: 10-18 parts of Bupleurum, 9-14 parts of Poria, 8-13 parts of Cuscuta, 9-12 parts of Radix Glycyrrhizae, 8-10 parts of Sangjishen, 13-13 parts of Rosa Fructus 16 parts, 7‑9 parts of Hedyotis diffusa, 9‑12 parts of Eclipta, 11‑14 parts of fairy spleen, and 5‑12 parts of dogwood. The treatment results show that the traditional Chinese medicine composition of the present invention can significantly reduce the recurrence of lupus nephritis in the maintenance stage. Compared with the existing immunosuppressant, the therapeutic effect is better, the stability is high, the recurrence rate is low, and the probability of complications is small. At the same time, it can also reduce the urine protein quantity of patients from ≤1.5g / d to ≤0.5g / d within one year, and realize the rapid and stable decline of urinary protein in patients with lupus nephritis.

Description

Technical field [0001] The present invention relates to the field of traditional Chinese medicine, and more particularly to a Chinese medicine composition for treating a sustaining stage of lupus nephritis. Background technique [0002] Lupus nephritis, LN) is a common and severe complication of systemic lupuserythenatosus, SLE, is also one of the common causes of secondary nephropathy leading to end-stage renal failure. The etiology of lupus nephritis, related factors have genetic factors, autoimmune function, pathogenic factors, protrusion infectious factors, etc. [0003] The ultimate goal of lupus nephritis is to prevent LN recurrence, protecting renal function, minimizing complications, promoting the recovery of patients. LN treatment can be divided into two parts: induce a phase of relief phase and the treatment maintenance stage. [0004] The purpose of induced relief stage is to make acute inflammation to alleviate as soon as possible (within 3-6 months), and minimize kid...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/748A61P13/12A61P37/02
CPCA61K36/076A61K36/185A61K36/233A61K36/28A61K36/296A61K36/39A61K36/40A61K36/43A61K36/484A61K36/738A61K36/748A61K2236/331A61P13/12A61P37/02A61K2300/00
Inventor 苏玉华张国俊
Owner AFFILIATED HOSPITAL OF WEIFANG MEDICAL UNIV
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