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A device and method for realizing passive fusion of micro-droplets

A micro-droplet and droplet technology, applied in laboratory containers, chemical instruments and methods, laboratory utensils, etc., can solve the problems of increasing the difficulty of micro-channels, complex micro-channel structures, etc., and achieve good market application potential, The effect of easy operation and low cost

Active Publication Date: 2021-07-30
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Compared with active fusion, the flow control system of passive fusion is simpler and has less interference with the characteristics of the droplet itself, but the microchannel structure is more complicated, which increases the difficulty of microchannel fabrication

Method used

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  • A device and method for realizing passive fusion of micro-droplets
  • A device and method for realizing passive fusion of micro-droplets
  • A device and method for realizing passive fusion of micro-droplets

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Embodiment

[0053] In the device of this embodiment, the width of the first microchannel 6 is 100 μm, the width of the second microchannel 7 and the third microchannel 8 is 30 μm, and the width between the second microchannel branch 7 and the first microchannel branch 6 is 30 μm. The included angle and the included angle α between the third microchannel branch 8 and the first microchannel branch 6 are both 90°. In this embodiment, the continuous phase fluid c injected into the first microchannel branch 6 through the first syringe pump 2 is deionized water, and the first dispersed phase fluid injected into the second microchannel branch 7 through the second syringe pump 3 Both d1 and the second dispersed phase fluid d2 injected into the third microchannel branch 8 by the third syringe pump 1 are mineral oil, wherein a dye is added to the second dispersed phase fluid d2 to make the first dispersed phase fluid d1 and the second dispersed phase fluid d2, it is easier to observe. The rest of ...

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Abstract

The invention discloses a device and method for realizing passive fusion of micro-droplets, wherein, the entrance ends of the main micro-channel are respectively connected with the first micro-channel branch, the second micro-channel branch and the third micro-channel branch The axis of the first microchannel branch is the same as the axis of the main microchannel, and the angle between the second microchannel branch and the first microchannel branch is the same as that between the third microchannel branch and the first microchannel branch. The included angles between the channels are the same; the first syringe pump injects the continuous phase fluid into the first microchannel branch, the second syringe pump injects the first dispersed phase fluid into the second microchannel branch, and the third syringe pump injects the third microchannel branch. The channel branch injects the second dispersed phase fluid. The present invention can realize efficient fusion between micro-droplets without the device having a complex micro-channel structure. At the same time, the present invention can be provided with multiple groups of syringe pumps and microchannels as required, so as to realize mutual fusion between multiple microdroplets.

Description

technical field [0001] The invention belongs to the technical field of droplet fusion, and in particular relates to a device and method for realizing passive fusion of micro-droplets. Background technique [0002] Droplet-Based Microfluidics is an important branch of microfluidic chip technology in recent years. Droplet microfluidic technology is a new technology for manipulating tiny volume droplets, that is, the microfluidic chip uses the interaction of two or more immiscible liquids to generate highly monodisperse nanoliter to femtoliter droplet. In the application of droplet microfluidics technology, the controllable fusion of droplets is an important means of mixing between different reagents or samples, and is widely used in the fields of particle synthesis, biochemical reactions, and drug screening. [0003] Currently, droplet fusion is mainly divided into two categories: active fusion and passive fusion. The active fusion of droplets refers to the effect of extern...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01L3/00
CPCB01L3/5027B01L3/50273
Inventor 钱锦远李晓娟金志江
Owner ZHEJIANG UNIV
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