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A kind of curcumin nanoparticle and preparation method thereof

A nanoparticle and curcumin technology, which is applied in the preparation method of peptides, chemical instruments and methods, and pharmaceutical formulations, can solve problems such as unstable water solubility, hindering wide application, and poor redispersibility of naked protein nanoparticles , to achieve high encapsulation efficiency, narrow PDI value, improved thermal stability and UV radiation stability

Active Publication Date: 2022-07-26
ZHEJIANG GONGSHANG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to its susceptibility to environmental influences (e.g., pH, ionic strength, and pepsin), it suffers from instability and low water solubility
In addition, the redispersibility of naked protein nanoparticles becomes poor after spray / freeze drying, which further hinders their widespread application.

Method used

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  • A kind of curcumin nanoparticle and preparation method thereof
  • A kind of curcumin nanoparticle and preparation method thereof
  • A kind of curcumin nanoparticle and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] A preparation method of curcumin nanoparticles, comprising the following steps:

[0044] (1) at room temperature (21° C.), add two grams of BSG protein extract and curcumin into 100 mL of water, and mix; the concentration of curcumin in this example is 0.5 mg / mL;

[0045] (2) use 3M NaOH to adjust the pH value of the mixed solution obtained in step (1) to 12.0, then carry out magnetic stirring at a speed of 600rpm, so that each component is uniformly dispersed;

[0046] (3) After 30 minutes of incubation, 10 mL of the dispersion obtained in step (2) was added dropwise to 40 mL of 0.2% (w / v) lecithin solution, and homogenized using an Ultra Turrax T25 homogenizer at a speed of 8000 rpm 3 minutes; the preparation method of the 0.2% (w / v) lecithin solution is as follows: 0.2 g of lecithin is dissolved in 100 mL of water.

[0047] (4) Neutralize the dispersion obtained in step (3) to pH 7.0, centrifuge at 2000 g for 10 minutes, discard the lower layer precipitate (ie, remo...

Embodiment 2

[0056] In the present embodiment, the concentration of curcumin is 1 mg / mL;

[0057] Other implementations in this embodiment are the same as those in Embodiment 1.

Embodiment 3

[0059] In the present embodiment, the concentration of curcumin is 2mg / mL;

[0060] Other implementations in this embodiment are the same as those in Embodiment 1.

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Abstract

The invention discloses a curcumin nanoparticle and a preparation method thereof. In the present invention, the BSG protein extract extracted with alkali and / or alcohol is used as the carrier of curcumin, and the curcumin nanoparticle in which the BSG protein extract and lecithin are complexed is prepared. The curcumin nano-particles prepared by the invention are spherical, uniform, have good dispersibility, narrow PDI value and high encapsulation efficiency. Curcumin was encapsulated in the hydrophobic core of BSG protein extract, and the solubility, thermal stability and UV-irradiation stability of encapsulated curcumin were significantly improved; and encapsulated curcumin had higher DPPH freedom than free curcumin Radical scavenging activity.

Description

technical field [0001] The invention specifically relates to a curcumin nanoparticle and a preparation method thereof. Background technique [0002] In recent decades, the use of colloidal drug delivery systems to encapsulate and protect biologically active substances such as phytochemicals, essential oils, and peptides to improve their physicochemical properties or control their release in the human gastrointestinal (GI) tract has received more and more attention. focus on. Naturally occurring food biomacromolecules such as proteins are considered ideal due to their biocompatibility / biodegradability and low toxicity compared to other synthetic polymers or surfactants Encapsulation / wrapping material. [0003] Curcumin is a chemical component extracted from the rhizomes of some plants in the Zingiberaceae and Araceae. Among them, turmeric contains about 3% to 6%, which is a very rare pigment with diketones in the plant kingdom, and is a diketone. compound. Curcumin is ora...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/51A61K47/42A61K47/24A61K31/12A61P39/06C07K1/14C07K1/30
CPCA61K9/5169A61K9/5123A61K9/5192A61K31/12A61P39/06C07K1/145C07K1/30
Inventor 章悦王磊
Owner ZHEJIANG GONGSHANG UNIVERSITY
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