Bionic cell membrane poly vesicle nano material as well as preparation method and application thereof

Abstract

The invention provides a bionic cell membrane poly vesicle nano material as well as a preparation method and application thereof, and belongs to the technical field of nano medicine. The vesicle comprises a hydrophilic shell and a hydrophobic inner core, wherein the hydrophilic shell is connected to the two ends of the hydrophobic inner core, and the hydrophilic shell and the hydrophobic inner core form a structure similar to a phospholipid bilayer structure; and the hydrophobic inner core is formed by coordinating hexadecyl trimethyl ammonium bromide on the surfaces of gold nanorods AuNRs with indocyanine green and then combining a coordination product with a PCL fragment, the hydrophilic shell consists of a PEG fragment, and the AuNRs are vertically erected on the outer layer of the vesicle. The bionic cell membrane poly vesicle structure provided by the invention can promote release of nano drugs in vesicles and subsequent intracytoplasmic displacement, so that the PTT/PDT combinedtreatment effect is enhanced; and protein adsorption in blood circulation can be shielded, protein crowns are prevented from being generated, the nano drug can be better accumulated at a tumor part, and the off-target effect is reduced.

Description

technical field [0001] The invention belongs to the technical field of tumor medicine, and relates to a vesicle nanomaterial, in particular to a bionic cell membrane polyvesicle nanomaterial and its preparation method and application. Background technique [0002] Over the past two decades, optics-based nanomedicine has been extensively studied in various aspects of biomedical applications such as precision diagnosis, imaging, drug delivery, and therapy. Photothermal therapy (PTT) and photodynamic therapy (PDT), due to their excellent properties such as non-invasive, efficient, effective intratumoral accumulation, excellent tissue penetration and better patient compliance, are very promising as traditional treatment methods and surgery alternative treatment methods. Photothermal therapy relies on the heat generated by photothermal transduction agents (PTAs) inside tumor cells after being irradiated by near-infrared light (NIR). Photothermal transduction agents can obtain e...

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