Compositions and methods for treating vaginal atrophy

A technology of vaginal atrophy and composition, applied in the directions of drug combination, drug delivery, pharmaceutical formulation, etc., can solve the problem of not recommending breast cancer survivors

Inactive Publication Date: 2020-12-25
THE PROCTER & GAMBLE COMPANY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, conventional estrogen-based therapy is generally not recommended for breast cancer survivors

Method used

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  • Compositions and methods for treating vaginal atrophy
  • Compositions and methods for treating vaginal atrophy
  • Compositions and methods for treating vaginal atrophy

Examples

Experimental program
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Effect test

preparation example Construction

[0043] The plants herein (i.e., plant-derived of) ingredients. Additionally or alternatively, fresh and / or dried plant material and / or plant serum fractions may be used. Some non-limiting examples of methods for preparing plant extracts and plant serum fractions are disclosed in US Patent Nos. 9,358,263 and 7,442,391, respectively.

[0044] optional ingredients

[0045]It may be desirable to include silicone oils in the vaginal care compositions herein to provide lightness, lubricity, and / or moisturizing benefits to vaginal skin. Silicone oils are typically liquids that contain one or more polymeric siloxane or silicone polymers (eg, polysiloxane, polydimethylsiloxane (PDMS), or combinations thereof). Silicone oils may be volatile (eg cyclomethicone D5) or non-volatile (eg dimethicone 50 cSt). The vaginal care composition may comprise 0.1% to 10% (eg, 0.5% to 8%, 1% to 5%, or even 2% to 4%) silicone oil, by weight of the vaginal care composition.

[0046] In some exampl...

Embodiment 1-18

[0062] Prepare the aqueous phase (A) by combining all ingredients in a beaker and heating to 75°C with stirring using a suitable mixer. Prepare the oil phase (B) in a separate glass beaker by combining all ingredients and heating to 75°C while stirring with a suitable stir plate and magnetic stir bar. The acidic aqueous phase (C) was prepared in a separate glass beaker by combining all ingredients and heating to 40°C while stirring with a suitable stir plate and magnetic stir bar.

[0063] Once the oil phase (B) reached 75°C, it was poured into the water phase (A) and mixed using a Tekmar mixer at 10,000 rpm for 5 minutes to form an oil-in-water emulsion. After mixing, the heat was turned off and the mixture was allowed to cool while stirring with an overhead mixer. When the mixture reaches 60 °C, add Sepigel TM 305. When the mixture reached 50°C, the acidic aqueous phase (C) was added. When the mixture reached 45°C, the remaining finishing ingredient (D) was added and the...

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Abstract

A method of treating vaginal atrophy is provided. The method comprises administering a vaginal care composition to vaginal tissue of a user experiencing a symptom of vaginal atrophy. The vaginal carecomposition may include an effective amount of a vaginal care agent selected to specifically treat symptoms of vaginal atrophy exhibited by the introitus and / or labia, based on the transcriptomic dataof skin cells obtained therefrom. In some instances, the vaginal care composition may be applied to introitus and / or labia with a suitable implement configured for such use.

Description

technical field [0001] Compositions and methods for treating vaginal atrophy are generally provided. Background technique [0002] Estimates suggest that by 2030, there will be approximately 1.2 billion menopausal and postmenopausal women in the world. Given that the average age at onset of menopause has remained constant and women's life expectancy has generally increased, the number of postmenopausal women is expected to increase. As a result, there is an increasing focus on conditions and symptoms experienced by perimenopausal, menopausal, and postmenopausal women, and thus a growing need for treatment. [0003] Menopause is known to be associated with a decrease in estrogen production, which can lead to a condition commonly referred to as vaginal atrophy. It is estimated that as many as 57 percent of perimenopausal and postmenopausal women suffer from vaginal atrophy. Vaginal atrophy can contribute to genitourinary infections and can also cause vaginal irritation, bur...

Claims

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Application Information

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Patent Type & AuthorityApplications(China)
IPC IPC(8): A61K36/9062A61K36/185A61K36/35A61K36/55A61K36/68A61K36/28A61P15/00
CPCA61K36/185A61K36/28A61K36/35A61K36/55A61K36/68A61K36/9062A61K9/0014A61K9/0034A61K9/107A61K31/728A61K45/06A61K47/32A61K47/44
Inventor特拉维斯·凯尔·霍登里奥·蒂莫西·劳克林三世王诚奕罗伯特·劳埃德·宾德
OwnerTHE PROCTER & GAMBLE COMPANY