Synthesis equipment of ursodeoxycholic acid and tauroursodeoxycholic acid

Abstract

The invention discloses synthesis equipment of ursodesoxycholic acid and tauroursodesoxycholic acid. The synthesis equipment comprises a stirring cylinder, a liquid discharging mechanism and a stirring mechanism, a supporting frame and a fixing block are arranged at the bottom end of the stirring cylinder, the liquid discharging mechanism is located on one side of the outer wall of the stirring cylinder, a metering pump is arranged at the top end of the stirring cylinder, and the input end of the metering pump is connected with a raw material pipeline; and the output end of the metering pump is connected with a liquid conveying pipeline, a stirring bin is arranged in the stirring cylinder, the stirring mechanism is located in the stirring bin, and a heater is arranged at the position, located on the outer wall of the stirring bin, in the stirring cylinder. By arranging an arc-shaped stirring knife, a solution at the lower end of the stirring bin can be turned upwards, the stirring andmixing degree of the solution is effectively improved, and the synthesis reaction of the solution is more thorough; and by arranging the multiple blades, when the solution flows through the blades, the blades can be driven to rotate with a connecting column as the center, impurities in the solution can be prevented from being accumulated at the pipe opening of the discharging pipeline through rotation of the blades, and therefore pipeline blockage is avoided.

Description

technical field [0001] The invention relates to the technical field of stirring synthesis equipment, in particular to a synthesis equipment of ursodeoxycholic acid and tauroursodeoxycholic acid. Background technique [0002] Deoxycholic acid, UDCA for short, is the main component of bear bile. Its chemical name is (3α, 7β)-dihydroxy-5βcholic acid, which is the 7-hydroxyl epimer of chenodeoxycholic acid. Since the discovery of ursodeoxycholic acid’s ability to effectively dissolve cholesterol gallstones in the 1980s, new studies have shown that ursodeoxycholic acid has a positive effect on gallbladder benefit and liver protection. [0003] The chemical name of tauroursodeoxycholic acid (TUDCA) is 3α, 7β dihydroxycholanoyl-N-taurine. Tauroursodeoxycholic acid is an active ingredient of bear bile, and it is mainly used clinically to treat cholesterol gallstones in the gallbladder. , primary sclerosing cholangitis, primary biliary cirrhosis and chronic hepatitis C virus. Clini...

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Problems solved by technology

[0006] In order to solve the problem of insufficient stirring during the synthesis operation and the easy blockage of the discharge pipe, the purpose of the present invention is to provide a synthesis equipment for ursodeoxycholic acid and tauroursodeoxycholic acid

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