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Composition containing orlistat and dihydropyrimidine compounds and application thereof

A technology of dihydropyrimidine and orlistat, applied in the field of biomedicine

Active Publication Date: 2021-01-05
ZHONGSHAN WANHAN PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the prior art, there is no technical revelation that the combined use of orlistat and dihydropyrimidines produces a synergistic inhibitory effect on HBV DNA replication

Method used

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  • Composition containing orlistat and dihydropyrimidine compounds and application thereof
  • Composition containing orlistat and dihydropyrimidine compounds and application thereof
  • Composition containing orlistat and dihydropyrimidine compounds and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 2

[0060] Embodiment 2 Oral solid preparation containing MIX (x-OsT) and preparation method thereof

[0061] prescription

[0062]

[0063]

[0064] Tablet Preparation Method

[0065] Mix the prescribed amount of MIX (x-OsT) with 1 / 3 of the amount of starch, add 15% starch slurry (containing tartaric acid) to make a soft material for 10-15 minutes, or make wet granules with a 14-mesh sieve, and dry at 70°C , the dry granules are passed through a 12-mesh sieve, and then the granules are mixed with the remaining starch (pre-dried at 100-105°C) and talcum powder adsorbed with liquid paraffin, and then passed through a 12-mesh sieve. , compressed into tablets each weighing about 200mg.

[0066] Capsule preparation method

[0067] Mix the prescribed amount of MIX (x-OsT) with 1 / 3 of the amount of starch, add 15% starch slurry (containing tartaric acid) to make a soft material for 10-15 minutes, or make wet granules with a 14-mesh sieve, and dry at 70°C , the dry granule...

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Abstract

The invention provides a composition containing orlistat and dihydropyrimidine compounds. The specific definition of the dihydropyrimidine compounds is shown in the specification. The in-vitro test result indicates that the orlistat and dihydropyrimidine compounds can generate a synergistic inhibiting action on HBV (hepatitis B virus) DNA (deoxyribonucleic acid) replication in Hep G2.2.15 cells within the mol ratio range (the combined drug index CI is less than 1).

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to a composition containing orlistat and dihydropyrimidine compounds and its application. Background technique [0002] Hepatitis B is a potentially fatal liver infectious disease caused by hepatitis B virus (HBV), which can increase the risk of death from liver cirrhosis and liver cancer. According to the World Health Organization (WHO), about 25.7 million people worldwide are infected with HBV, and a total of 887,000 people died of HBV in 2015, most of them died of HBV-induced diseases including liver cirrhosis and hepatocellular carcinoma. Therefore, HBV is a public health challenge faced by countries all over the world. Esser K et al found in the article Lipase inhibitor orlistat prevents hepatitis B virus infection by targeting an earlystep in the virus life cycle (source: Antiviral Res.2018Jan 5; 151:4-7.), lipase inhibitor weight loss drug orlistat He (orlistat) can p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/365A61K31/506A61P31/20
CPCA61K31/365A61K31/506A61P31/20A61K2300/00
Inventor 李鉴有李翠玉黄海石吴彦勍杜志博彭韪
Owner ZHONGSHAN WANHAN PHARM CO LTD
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