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A kind of preparation method and application of antioxidant polyphenol nanomaterial

A technology of natural polyphenols and nanomaterials, applied in the field of biomedical materials, can solve the problems of complicated preparation, single product, poor effect, etc., and achieve the effect of efficiently triggering polymerization reaction, strong practicability, and reducing inflammation.

Active Publication Date: 2021-06-15
SICHUAN UNIV
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Problems solved by technology

However, the existing polyphenol macromolecularization methods are often only effective for a single polyphenol, and different polyphenols may need to be designed separately
Therefore, the current natural polyphenol macromolecular products generally have problems such as poor effect, cumbersome preparation, and single product.

Method used

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  • A kind of preparation method and application of antioxidant polyphenol nanomaterial
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  • A kind of preparation method and application of antioxidant polyphenol nanomaterial

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Embodiment Construction

[0040]In the present invention, under the action of ultrasonic waves, the reaction solution will generate a certain amount of hydrogen peroxide due to the cavitation effect of the sound waves, and at the same time combine the horseradish peroxidase that can catalyze the polymerization of phenols indiscriminately to catalyze the polymerization of polyphenol monomers. Horseradish peroxidase quickly catalyzes hydrogen peroxide produced by ultrasonic waves into hydrogen peroxide free radicals, and at the same time oxidizes polyphenol monomers into free radicals and releases water molecules, and then the coupling of the two molecules of free radicals is terminated. The method of the invention can realize the indiscriminate polymerization of various polyphenols, and its essence is a free radical polymerization method in aqueous solution, which is a very universal preparation method. Furthermore, the reaction can be regulated and controlled by adjusting the amount of enzyme, ultrasoni...

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Abstract

The invention discloses a preparation method and application of anti-oxidation poly-natural polyphenol nanomaterials, comprising: dissolving natural polyphenols to obtain a natural polyphenol solution, mixing with horseradish peroxidase to obtain a reaction solution, and subjecting the reaction solution to Ultrasonic treatment, the ultrasonic frequency is 40KHz, the ultrasonic power is 400-600W, and the ultrasonic treatment works in the pulse mode of 1.6s on / 0.4s off; at the same time, the reaction temperature is controlled at 45-65°C, and after 0.5-12 hours of reaction, the The reaction solution is centrifuged and washed to obtain poly-natural polyphenol nanomaterials. The invention is simple and convenient, adjustable and controllable, has strong practicability, and has universal applicability to macromolecularization of various natural polyphenol small molecule compounds. The polynatural polyphenol nanomaterial prepared by the invention has excellent oxidation resistance, can effectively exert excellent antioxidant effects in vitro and in cell biology, and can also effectively accelerate wound healing.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a preparation method and application of an anti-oxidation poly-natural polyphenol nanomaterial. Background technique [0002] Skin exists on the surface of the human body. It is an important organ for the human body to resist external invasion and internal environment. It is also the largest organ of the human body. It is of great significance in both anatomy and physiology. Therefore, the integrity of the skin is extremely important for the health and safety of the human body. However, in the complex and changeable external environment, the skin often suffers a certain degree of damage and damage, destroying the integrity of the skin as the first line of defense of the human body, causing adverse reactions such as pain and inflammation in the slightest, and endangering life safety in severe cases. Therefore, it is particularly important to repair the skin as soon as...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G65/38C08G65/40A61L15/22A61L15/42A61L15/44C12P7/00
CPCA61L15/22A61L15/42A61L15/44A61L2300/41A61L2300/412C08G65/38C08G65/4087C08G65/4093C12P7/00C08L71/00
Inventor 李乙文王天佑顾志鹏
Owner SICHUAN UNIV
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