Novel application of rendan mini-pill traditional Chinese medicine composition in alleviation of hangover or treatment of alcoholic liver injury

A technology for alcoholic liver injury and a composition, which is applied in the fields of medical technology and health care products, can solve the problems such as the limited effect of reversing alcoholic liver injury and restoring liver function, and achieves reducing body weight and liver index, preventing or treating alcoholic liver disease. Effects of damage, prolongation of alcohol tolerance time

Active Publication Date: 2021-02-05
SHANGHAI ZHONGHUA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These drugs are broad-spectrum liver injury drugs, which can slow down the development of the disease to a certain extent, and restore liver biochemical indicators to normal, but the effect of reversing alcoholic liver injury and restoring liver function is limited

Method used

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  • Novel application of rendan mini-pill traditional Chinese medicine composition in alleviation of hangover or treatment of alcoholic liver injury
  • Novel application of rendan mini-pill traditional Chinese medicine composition in alleviation of hangover or treatment of alcoholic liver injury
  • Novel application of rendan mini-pill traditional Chinese medicine composition in alleviation of hangover or treatment of alcoholic liver injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Example 1 Anti-drunk and hangover experiment

[0033]Sixteen healthy C57 mice were randomly divided into a drunk model group and a Longhuren Dan prevention group, with 8 mice in each group. The model group was administered with normal saline, and the Longhurendan prevention group was administered with 250mg / kg dose, followed by 56% vol of Niulanshan Erguotou (previously determined by pre-experiment for drunken mice) at a dose of 15ml / kg. Observe and record the tolerance time (from sobriety to the time when the righting reflex disappears) of the mice drunkenness, and calculate the drunkenness rate.

[0034] The results are shown in Table 1 below. Compared with the drunken model group, after pretreatment with Longhurendan, the degree of drunkenness of the mice was significantly improved, and the drunkenness tolerance time of the mice was significantly prolonged (P<0.01). It shows that Longhuren Dan has a certain anti-drunk and anti-alcoholic effect on drunk mice.

[003...

Embodiment 2

[0038] Example 2 Alcoholic liver injury experiment in mice

[0039] 1. Modeling

[0040] 36 healthy male C57 mice were randomly divided into 6 groups: blank group, model group, Longhurendan low-dose group (20mg / kg), Longhurendan medium-dose group (40mg / kg), Longhurendan High dose group (80mg / kg) and silybin group (70mg / kg). 3:00-5:00pm every day, the corresponding drugs were given by gavage, and the blank group and the model group were given CMC-Na. After 30 minutes of administration on the 11th day, the blank group was gavaged with 9 mg / kg maltodextrin solution, and the other groups were given 5 mg / kg ethanol solution. After 9 hours, the mice were anesthetized, and the serum and liver tissue were collected for subsequent testing. The specific experimental procedures are as follows: figure 1 shown.

[0041] Table 2 Grouping and administration

[0042]

[0043] 2. Effects of mouse model body weight and liver weight

[0044] The results of mouse model body weight and li...

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Abstract

The invention belongs to the field of medical technology and health care products, and particularly relates to a novel application of rendan mini-pill traditional Chinese medicine composition in alleviation of hangover or treatment of alcoholic liver injury. The invention finds that the rendan mini-pill traditional Chinese medicine composition has a good hangover alleviating effect, and can prolong the alcohol tolerance time of drunken mice. The invention also finds that the rendan mini-pill traditional Chinese medicine composition has prevention and treatment effects on alcoholic liver injury, can reduce the weight and liver index of mice with acute alcoholic liver injury, and effectively improves the liver injury and ALT and AST activity of serum of the mice with alcoholic liver injury;and meanwhile, the expression of alcohol metabolism key enzyme cytochrome P450 2E1 (CYP2E1) protein can be obviously reduced.

Description

technical field [0001] The invention belongs to the field of medical technology and health care products, and in particular relates to the new application of Rendan traditional Chinese medicine composition for preventing drunkenness and hangover or treating alcoholic liver injury. Background technique [0002] With the rapid development of economy and society, more and more people regard drinking as a common means of socializing and entertainment, and wine table culture is deeply rooted in people's social and cultural life. However, long-term excessive drinking habits are often an important factor causing alcoholic liver disease, causing irreversible damage to human health. In recent years, epidemiological investigations of alcoholic liver disease have shown that the number of alcohol consumers worldwide is growing, and the number of people suffering from alcoholic liver disease is also increasing. [0003] A large number of studies have shown that long-term heavy drinking ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61P1/16A61P39/00A61K31/045
CPCA61K31/045A61K36/61A61K36/9064A61K36/57A61K36/54A61K36/67A61K36/285A61K36/9068A61K36/48A61K36/484A61P1/16A61P39/00A61K2300/00
Inventor 丁礼琴金家骅展学强朱晓萍陈晓黄琳雁
Owner SHANGHAI ZHONGHUA PHARMA
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