Simultaneous multi-site vagus nerve neuromodulation for improved glycemic control system and methods

A neurological and blood sugar technology, applied in the patient's system, to treat the subject's diseases related to impaired glucose regulation, which can solve the problems of inability to acquire cognitive ability, consumption of foods containing monosaccharides, and unsatisfactory treatment methods.

Pending Publication Date: 2021-02-26
RESHAPE LIFESCIENCES INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, this treatment is not ideal
For example, the onset of hypoglycemia is rapid, on the order of minutes, and

Method used

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  • Simultaneous multi-site vagus nerve neuromodulation for improved glycemic control system and methods
  • Simultaneous multi-site vagus nerve neuromodulation for improved glycemic control system and methods
  • Simultaneous multi-site vagus nerve neuromodulation for improved glycemic control system and methods

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Experimental program
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Embodiment

[0152] The results herein demonstrate that electrical modulation of nerves innervating the pancreas and liver improves IVGTT performance in the Zucker fat (fat) rat (ZDF fa / fa) model of type 2 diabetes. In this study, stimulation of the celiac branch of the vagus nerve (innervating the pancreas) was accompanied by simultaneous ligation of the hepatic branch of the vagus nerve or application of HFAC on the hepatic nerve.

[0153] Zucker obese diabetic rats (ZDF fa / fa) were anesthetized by IP injection of pentobarbital or Sprague Dawley control rats. Next, the rat was placed on a heating blanket and the right jugular vein was cannulated. Assess the depth of anesthesia by periodically testing the paw withdrawal response. If reflexes are observed, a maintenance dose of pentobarbital is administered intravenously. Next, the abdominal cavity is opened and the liver is retracted. The hepatic branch of the ventral vagus and the celiac branch of the dorsal vagus are separated an...

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Abstract

Various methods and apparatus for treating a condition associated with impaired glucose regulation in a subject comprising in one embodiment, applying a neural conduction block to a target nerve at ablocking site with the neural conduction block selected to at least partially block nerve pulses. In another embodiment, combinations of down-regulating and or up-regulating with are used to treat impaired glucose regulation. In other embodiments, up-regulation or downregulation of various nerves, such as the vagus and its branches, are used to modify the secretion of insulin and glucagon from thepancreas, thereby controlling glucose levels. In yet further embodiments, combinations of down-regulating and or up-regulating are used to control sensitivity of the liver to plasma insulin and glucagon to treat impaired glucose regulation.

Description

[0001] Cross References to Related Applications [0002] This application was filed as a PCT International Patent Application on April 12, 2019, and claims the benefit of U.S. Patent Application 62 / 656,787, filed April 12, 2018, the entire disclosure of which is incorporated herein. Background technique [0003] In the United States, an estimated 29 million people have diabetes, a serious lifelong condition. The main forms of diabetes are type 1 and type 2. Type 1 diabetes is an autoimmune disease that causes the destruction of beta cells in the pancreas, which consequently produce little or no insulin. People with type 1 diabetes must take insulin daily to survive. The most common form of diabetes is type 2 diabetes. In the United States, about 10 percent of people ages 40 to 59 and 20 percent of people over age 60 have type 2 diabetes. The disease is the sixth leading cause of death and leads to the development of heart disease, stroke, high blood pressure, kidney diseas...

Claims

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Application Information

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IPC IPC(8): A61N1/36A61N1/372
CPCA61N1/0509A61N1/36053A61N1/37223A61N1/37247A61N1/37217A61N1/37241A61N1/0551A61N1/3606A61N1/36171A61N1/37235
Inventor J.J.瓦塔贾R.尼哈拉尼
Owner RESHAPE LIFESCIENCES INC
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