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Use of columbianetin and medicine for treating acute pancreatitis

A technology of dihydro-aperegrol, acute pancreatitis, applied in the field of medicine

Inactive Publication Date: 2021-03-26
烟台拉斐尔生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are still very few studies on the effect of dihydroparieline on acute pancreatitis, so further research is needed.

Method used

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  • Use of columbianetin and medicine for treating acute pancreatitis
  • Use of columbianetin and medicine for treating acute pancreatitis
  • Use of columbianetin and medicine for treating acute pancreatitis

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Embodiment Construction

[0014] The technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention. Apparently, the described embodiments are only some of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0015] In one embodiment of the present invention, by establishing an animal model of acute pancreatitis in rats, the application of dihydro-eoserveol combined with ulinastatin is used for intervening treatment, and the treatment of early acute pancreatitis with dihydro-eoserveol combined with ulinastatin is explored. The effect and the relieving effect of dihydro-eugenol on the side effects of drugs caused by ulinastatin provide reference for clinical treatment. The specific...

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Abstract

The invention is applicable to the technical field of medicines and provides use of columbianetin and a medicine for treating acute pancreatitis. The columbianetin and ulinastatin are combined to reduce pancreatic tissue damage of rats with acute pancreatitis, improve microcirculation during pancreatitis, inhibit inflammatory factor secretion, reduce inflammatory reaction degree, and have a treatment effect better than that of single use of ulinastatin. In addition, the columbianetin also has a certain improvement effect on a side effect of the ulinastatin on reducing leucocytes.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to the application of dihydro-serveol and a medicine for treating acute pancreatitis. Background technique [0002] Acute pancreatitis (AP) is a common clinical inflammatory disease of pancreatic tissue, which is caused by abnormal activation of trypsinogen, and its incidence rate is increasing year by year. Increased trypsin. Pancreatic edema in mild cases, pancreatic hemorrhage, necrosis, peritonitis and shock in severe cases, and multiple organ failure may also be involved. In recent years, the incidence of AP has increased year by year, about 20% of patients will develop severe acute pancreatitis (SAP), and some patients even died due to the systemic inflammatory response syndrome and multiple organ failure caused by it. Early AP is typically characterized by digestive enzyme-induced focal necrosis of pancreatic acinar cells, which then triggers pro-inflammatory ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/37A61K38/57A61P1/18
CPCA61K31/37A61K38/57A61P1/18A61K2300/00
Inventor 李大磊闫萌军樊荣周冲王绍斐王思捷衣晓靖刘同慎黄严
Owner 烟台拉斐尔生物科技有限公司
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