Fluorescence molecular tomography method and system based on multi-wavelength concurrent reconstruction

Abstract

The invention relates to a fluorescence molecular tomography method and system based on multi-wavelength concurrent reconstruction. The method comprises the following steps: collecting distribution information of light sources in a to-be-imaged tissue; establishing a forward transmission model of the multiple photons in the tissue to be imaged based on a diffusion equation and a finite element subdivision method according to the distribution information; collecting fluorescence light intensity values of the to-be-imaged tissue under different wavelengths according to the forward transmission model; determining a fluorescence intensity value data set after dimension amplification by adopting a concurrent wavelength reconstruction algorithm and a principal component analysis method according to the fluorescence intensity values under different wavelengths; dividing the fluorescence intensity value data set into a training data set and a prediction data set; training the stack type self-encoding neural network model, and determining a heteroplasmon prediction model; determining a fluorescence yield value by adopting a heteroplasmon prediction model; and determining a heteroplasmon fluorescence yield reconstruction image according to the fluorescence yield value. According to the invention, the problem of ill-conditioned inverse in the FMT imaging process is effectively solved, and the imaging precision is greatly improved.

Description

technical field [0001] The invention relates to the field of biomedical molecular imaging, in particular to a method and system for fluorescent molecular tomography based on multi-wavelength concurrent reconstruction. Background technique [0002] Breast cancer is one of the most important malignant tumors affecting women's health around the world. It has become a common and frequently-occurring disease that seriously affects women's physical and mental health and even threatens their lives. According to statistics, in 2012, there were about 1.671 million new cases of female breast cancer in the world, ranking first in the incidence of female malignant tumors; about 525,000 deaths, ranking first in the death of female malignant tumors. Early diagnosis of breast cancer can provide patients with more adequate treatment time and greatly improve the survival probability of patients. [0003] As an emerging molecular imaging technology, optical molecular imaging integrates multi...

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Problems solved by technology

[0005] The purpose of the present invention is to provide a fluorescence molecular tomography method and system based on multi-wavelength concurrent reconstruction, which can effectively solve the ill-conditioned inverse problem in the FMT imaging process and greatly improve the imaging accuracy

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