The invention discloses a
fluorescence molecular
tomography reconstruction method. The method comprises the following steps: S1, establishing a
system equation for the measured data of a surface and the distribution of a fluorescent target inside an imaging object by taking the optical
feature parameter and anatomical structure information of the imaging object as
prior information based on an optical transmission model and a finite element theory; S2, preprocessing the
system equation established in the step S1 in order that rows of a
sparse matrix in the preprocessed
system equation are orthogonal to each other; S3, fusing the sparse property of
light source spatial distribution, selecting a plurality of rows from the system equation established in the step S1, and establishing a new
coefficient matrix and a new system equation; S4, converting the new system equation established in the step S3 into a
minimization problem with a constraint condition, and solving the new system equation by adopting a simultaneous algebraic reconstruction technique to obtain the three-dimensional distribution and concentration of the fluorescent target inside the imaging object. The method has the beneficial effects that the sparse property of the fluorescent target
spatial distribution is fused, the
prior information is increased, and the reconstruction accuracy can be increased; the system equation is preprocessed, and the rows of the
coefficient matrix of the system equation are orthogonal to each other, so that the
algorithm convergence can be accelerated, and the reconstruction speed is increased.