Dual-mode in vivo imaging system and method based on wavelet data compression

Abstract

The invention discloses a double-mode in-vivo imaging system and method based on wavelet data compression, belonging to the technical field of molecule images. The double-mode in-vivo imaging system comprises a micro CT (Computed Tomography) subsystem and a fluorescence molecular tomography subsystem. Two subsystems are arranged in an orthogonal manner. The fluorescence molecular tomography subsystem is provided with a two-dimensional acousto-optic deflector. The double-mode in-vivo imaging method comprises the following steps of: collecting an X-ray projection image and a fluorescence image; using the two-dimensional acousto-optic deflector to control exciting light to scan in a process of collecting the fluorescence image; obtaining a position and a direction of an exciting point; obtaining a detection pattern set by compressing the fluorescence image; obtaining a measurement value vector and a Jacobian matrix according to the position and the direction of the exciting point and the detection pattern set; carrying out matrix inversion to obtain a fluorescence probe distribution according to the measurement value vector and the Jacobian matrix. According to the double-mode in-vivo imaging system and method provided by the invention, the faster collection of original data is realized, and the rapid reestablishment can be carried out by using a collected oversized data set.

Description

technical field [0001] The invention belongs to the technical field of molecular imaging, and relates to an imaging system and method, in particular to a dual-mode living body imaging system and method based on wavelet data compression that combines micro-CT and fluorescent molecular tomography. Background technique [0002] Micro-CT uses the difference in the absorption coefficient of biological tissues to X-ray imaging, which is a high-resolution three-dimensional structural imaging technology; fluorescence molecular tomography technology can perform in vivo three-dimensional quantitative imaging of fluorescent probes specifically labeled in small animals , which can be used to observe functional changes of specific cells and molecules. The combination of micro-CT and fluorescence molecular tomography technology can simultaneously obtain structural information and functional information of small animals, providing a wealth of information that cannot be provided by a single...

AI Technical Summary

Problems solved by technology

However, in these applications, only the characteristics of fast response and high positioning accuracy of the acousto-optic deflector are used to achieve fast scanning of the entire region of interest.

In fluorescence molecular tomography, the scanning mode of excitation light will not only affect the acquisition speed of raw data, but also affect the speed of reconstruction algorithm, so it is necessary to establish an excitation light scanning mode suitable for fast acquisition and reconstruction

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